FNBP1L

Entrez Summary: N/A
UniProt Summary: Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens. {ECO:0000269|PubMed:15260990, ECO:0000269|PubMed:16326391, ECO:0000269|PubMed:19342671}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
YM155 0.0002μM R01 exp61	-2.08
BAY-598 4μM R05 exp220	2.37

vesicle transport along actin filament
actin filament-based transport
plasma membrane tubulation
clathrin-dependent endocytosis
positive regulation of filopodium assembly
GTPase binding
regulation of filopodium assembly
vesicle cytoskeletal trafficking
plasma membrane organization
vesicle budding from membrane
positive regulation of plasma membrane bounded cell projection assembly
actin filament-based movement
cell cortex
membrane invagination
lipid binding
establishment of vesicle localization
cytoskeleton-dependent intracellular transport
vesicle localization
regulation of plasma membrane bounded cell projection assembly
regulation of cell projection assembly
receptor-mediated endocytosis
cytoplasmic vesicle
process utilizing autophagic mechanism
autophagy
vesicle organization
cadherin binding
cilium assembly
establishment of organelle localization
cytoskeleton
cilium organization
positive regulation of cell projection organization
endomembrane system organization
plasma membrane bounded cell projection assembly
cell projection assembly
positive regulation of cellular component biogenesis
endocytosis
actin filament-based process
organelle localization
import into cell
regulation of plasma membrane bounded cell projection organization