FOSB

Entrez Summary: The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

bZIP 1
bZIP 2

response to corticosterone
response to mineralocorticoid
response to morphine
response to isoquinoline alkaloid
response to progesterone
response to anesthetic
cellular response to calcium ion
response to cAMP
response to alkaloid
response to organophosphorus
response to glucocorticoid
response to calcium ion
response to purine-containing compound
response to corticosteroid
female pregnancy
response to ammonium ion
cellular response to metal ion
response to ketone
multi-multicellular organism process
response to mechanical stimulus
cellular response to inorganic substance
response to alcohol
response to xenobiotic stimulus
response to steroid hormone
transcription factor binding
response to metal ion
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription by RNA polymerase II
RNA polymerase II proximal promoter sequence-specific DNA binding
response to inorganic substance
cellular response to hormone stimulus
transcription, DNA-templated
nucleic acid-templated transcription
RNA biosynthetic process
intracellular membrane-bounded organelle
response to lipid
negative regulation of transcription by RNA polymerase II
response to hormone
response to organic cyclic compound
multi-organism reproductive process