FOXC2 [The Human Chemical-Genetic Interaction Map Project]

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======= FOXC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXC2
  * **<color #00a2e8>Official Name</color>**: forkhead box C2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2303|2303]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99958|Q99958]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602402|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain.  The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional activator. Might be involved in the formation of special mesenchymal tissues. {ECO:0000269|PubMed:9169153}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fork head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|paraxial mesodermal cell differentiation|
|negative regulation of apoptotic process involved in outflow tract morphogenesis|
|paraxial mesodermal cell fate commitment|
|regulation of apoptotic process involved in outflow tract morphogenesis|
|glomerular endothelium development|
|positive regulation of vascular wound healing|
|glomerular mesangial cell development|
|negative regulation of apoptotic process involved in development|
|mesangial cell development|
|negative regulation of apoptotic process involved in morphogenesis|
|glomerular mesangial cell differentiation|
|regulation of vascular wound healing|
|paraxial mesoderm formation|
|mesangial cell differentiation|
|glomerular mesangium development|
|pericyte cell differentiation|
|paraxial mesoderm morphogenesis|
|embryonic viscerocranium morphogenesis|
|regulation of apoptotic process involved in morphogenesis|
|lymphangiogenesis|
|regulation of apoptotic process involved in development|
|mesodermal cell fate commitment|
|cardiac muscle cell proliferation|
|lymph vessel morphogenesis|
|striated muscle cell proliferation|
|renal filtration cell differentiation|
|glomerular visceral epithelial cell differentiation|
|glomerular epithelial cell differentiation|
|paraxial mesoderm development|
|muscle cell proliferation|
|glomerulus vasculature development|
|positive regulation of cell adhesion mediated by integrin|
|glomerular epithelium development|
|kidney vasculature development|
|renal system vasculature development|
|positive regulation of cell migration involved in sprouting angiogenesis|
|lymph vessel development|
|mesodermal cell differentiation|
|cardiac muscle tissue growth|
|branching involved in blood vessel morphogenesis|
|heart growth|
|cell fate commitment involved in formation of primary germ layer|
|epithelial cell differentiation involved in kidney development|
|blood vessel remodeling|
|negative regulation of animal organ morphogenesis|
|regulation of cell migration involved in sprouting angiogenesis|
|positive regulation of sprouting angiogenesis|
|regulation of heart morphogenesis|
|cell differentiation involved in kidney development|
|embryonic cranial skeleton morphogenesis|
|regulation of cell adhesion mediated by integrin|
|negative regulation of cold-induced thermogenesis|
|collagen fibril organization|
|ventricular cardiac muscle tissue morphogenesis|
|promoter-specific chromatin binding|
|mesenchyme morphogenesis|
|glomerulus development|
|positive regulation of wound healing|
|ventricular cardiac muscle tissue development|
|positive regulation of blood vessel endothelial cell migration|
|artery morphogenesis|
|positive regulation of response to wounding|
|somitogenesis|
|cranial skeletal system development|
|vascular endothelial growth factor receptor signaling pathway|
|mesoderm formation|
|cardiac muscle tissue morphogenesis|
|regulation of sprouting angiogenesis|
|mesoderm morphogenesis|
|chromatin DNA binding|
|cardiac ventricle morphogenesis|
|embryonic heart tube development|
|neural crest cell development|
|muscle tissue morphogenesis|
|somite development|
|mesenchymal cell development|
|stem cell development|
|metanephros development|
|ureteric bud development|
|artery development|
|mesonephric tubule development|
|mesonephric epithelium development|
|muscle organ morphogenesis|
|insulin receptor signaling pathway|
|neural crest cell differentiation|
|regulation of blood vessel endothelial cell migration|
|mesonephros development|
|regulation of organ growth|
|embryonic skeletal system morphogenesis|
|segmentation|
|endothelium development|
|organ growth|
|nephron epithelium development|
|positive regulation of endothelial cell migration|
|tissue remodeling|
|formation of primary germ layer|
|nephron development|
|mesoderm development|
|Notch signaling pathway|
|embryonic skeletal system development|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|kidney epithelium development|
|branching morphogenesis of an epithelial tube|
|regulation of wound healing|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|regulation of tube size|
|positive regulation of epithelial cell migration|
|regulation of cold-induced thermogenesis|
|mesenchymal cell differentiation|
|stem cell differentiation|
|regulation of endothelial cell migration|
|gastrulation|
|morphogenesis of a branching epithelium|
|cardiac muscle tissue development|
|cellular response to insulin stimulus|
|positive regulation of angiogenesis|
|regulation of response to wounding|
|morphogenesis of a branching structure|
|vascular process in circulatory system|
|cardiac chamber development|
|positive regulation of vasculature development|
|epithelial cell development|
|anterior/posterior pattern specification|
|transcription regulatory region DNA binding|
|regulation of epithelial cell migration|
|mesenchyme development|
|connective tissue development|
|response to insulin|
|skeletal system morphogenesis|
|cell fate commitment|
|heart morphogenesis|
|regulation of animal organ morphogenesis|
|ossification|
|cellular response to peptide hormone stimulus|
|kidney development|
|nuclear body|
|renal system development|
|striated muscle tissue development|
|regulation of angiogenesis|
|embryonic organ morphogenesis|
|muscle organ development|
|muscle tissue development|
|epithelial tube morphogenesis|
|camera-type eye development|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|angiogenesis|
|urogenital system development|
|regulation of vasculature development|
|cellular response to peptide|
|regulation of developmental growth|
|regionalization|
|extracellular matrix organization|
|eye development|
|visual system development|
|sensory system development|
|extracellular structure organization|
|developmental growth|
|blood circulation|
|response to peptide hormone|
|growth|
|circulatory system process|
|positive regulation of cell adhesion|
|blood vessel morphogenesis|
|sequence-specific DNA binding|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|supramolecular fiber organization|
|response to peptide|
|muscle structure development|
|blood vessel development|
|skeletal system development|
|positive regulation of cell migration|
|RNA polymerase II proximal promoter sequence-specific DNA binding|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|positive regulation of cell motility|
|heart development|
|positive regulation of cellular component movement|
|sensory organ development|
|positive regulation of locomotion|
|cell population proliferation|
|tissue morphogenesis|
|embryonic morphogenesis|
|cellular response to organonitrogen compound|
|cellular response to hormone stimulus|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|cellular response to nitrogen compound|
|regulation of growth|
|DNA-binding transcription factor activity|
|regulation of cell adhesion|
|epithelial cell differentiation|
|enzyme linked receptor protein signaling pathway|
|tube development|
|regulation of cell migration|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|negative regulation of apoptotic process|
|anatomical structure formation involved in morphogenesis|
|negative regulation of programmed cell death|
|response to hormone|
|regulation of cell motility|
|negative regulation of developmental process|
|animal organ morphogenesis|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|negative regulation of cell death|
|response to organonitrogen compound|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|identical protein binding|
|response to nitrogen compound|
|epithelium development|
|negative regulation of transcription, DNA-templated|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|regulation of cell death|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 6/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|1/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4134
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXC2 Expression in NALM6 Cells: -2.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>