FOXC2
Gene Information
- Official Symbol: FOXC2
- Official Name: forkhead box C2
- Aliases and Previous Symbols: N/A
- Entrez ID: 2303
- UniProt: Q99958
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: This gene belongs to the forkhead family of transcription factors which is characterized by a distinct DNA-binding forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the development of mesenchymal tissues. [provided by RefSeq, Jul 2008].
- UniProt Summary: Transcriptional activator. Might be involved in the formation of special mesenchymal tissues. {ECO:0000269|PubMed:9169153}.
Pfam Domains GO Terms
Pfam Domains
| Fork head |
GO Terms
| paraxial mesodermal cell differentiation |
| negative regulation of apoptotic process involved in outflow tract morphogenesis |
| paraxial mesodermal cell fate commitment |
| regulation of apoptotic process involved in outflow tract morphogenesis |
| glomerular endothelium development |
| positive regulation of vascular wound healing |
| glomerular mesangial cell development |
| negative regulation of apoptotic process involved in development |
| mesangial cell development |
| negative regulation of apoptotic process involved in morphogenesis |
| glomerular mesangial cell differentiation |
| regulation of vascular wound healing |
| paraxial mesoderm formation |
| mesangial cell differentiation |
| glomerular mesangium development |
| pericyte cell differentiation |
| paraxial mesoderm morphogenesis |
| embryonic viscerocranium morphogenesis |
| regulation of apoptotic process involved in morphogenesis |
| lymphangiogenesis |
| regulation of apoptotic process involved in development |
| mesodermal cell fate commitment |
| cardiac muscle cell proliferation |
| lymph vessel morphogenesis |
| striated muscle cell proliferation |
| renal filtration cell differentiation |
| glomerular visceral epithelial cell differentiation |
| glomerular epithelial cell differentiation |
| paraxial mesoderm development |
| muscle cell proliferation |
| glomerulus vasculature development |
| positive regulation of cell adhesion mediated by integrin |
| glomerular epithelium development |
| kidney vasculature development |
| renal system vasculature development |
| positive regulation of cell migration involved in sprouting angiogenesis |
| lymph vessel development |
| mesodermal cell differentiation |
| cardiac muscle tissue growth |
| branching involved in blood vessel morphogenesis |
| heart growth |
| cell fate commitment involved in formation of primary germ layer |
| epithelial cell differentiation involved in kidney development |
| blood vessel remodeling |
| negative regulation of animal organ morphogenesis |
| regulation of cell migration involved in sprouting angiogenesis |
| positive regulation of sprouting angiogenesis |
| regulation of heart morphogenesis |
| cell differentiation involved in kidney development |
| embryonic cranial skeleton morphogenesis |
| regulation of cell adhesion mediated by integrin |
| negative regulation of cold-induced thermogenesis |
| collagen fibril organization |
| ventricular cardiac muscle tissue morphogenesis |
| promoter-specific chromatin binding |
| mesenchyme morphogenesis |
| glomerulus development |
| positive regulation of wound healing |
| ventricular cardiac muscle tissue development |
| positive regulation of blood vessel endothelial cell migration |
| artery morphogenesis |
| positive regulation of response to wounding |
| somitogenesis |
| cranial skeletal system development |
| vascular endothelial growth factor receptor signaling pathway |
| mesoderm formation |
| cardiac muscle tissue morphogenesis |
| regulation of sprouting angiogenesis |
| mesoderm morphogenesis |
| chromatin DNA binding |
| cardiac ventricle morphogenesis |
| embryonic heart tube development |
| neural crest cell development |
| muscle tissue morphogenesis |
| somite development |
| mesenchymal cell development |
| stem cell development |
| metanephros development |
| ureteric bud development |
| artery development |
| mesonephric tubule development |
| mesonephric epithelium development |
| muscle organ morphogenesis |
| insulin receptor signaling pathway |
| neural crest cell differentiation |
| regulation of blood vessel endothelial cell migration |
| mesonephros development |
| regulation of organ growth |
| embryonic skeletal system morphogenesis |
| segmentation |
| endothelium development |
| organ growth |
| nephron epithelium development |
| positive regulation of endothelial cell migration |
| tissue remodeling |
| formation of primary germ layer |
| nephron development |
| mesoderm development |
| Notch signaling pathway |
| embryonic skeletal system development |
| cardiac chamber morphogenesis |
| cardiac ventricle development |
| kidney epithelium development |
| branching morphogenesis of an epithelial tube |
| regulation of wound healing |
| regulation of tube diameter |
| regulation of blood vessel diameter |
| regulation of tube size |
| positive regulation of epithelial cell migration |
| regulation of cold-induced thermogenesis |
| mesenchymal cell differentiation |
| stem cell differentiation |
| regulation of endothelial cell migration |
| gastrulation |
| morphogenesis of a branching epithelium |
| cardiac muscle tissue development |
| cellular response to insulin stimulus |
| positive regulation of angiogenesis |
| regulation of response to wounding |
| morphogenesis of a branching structure |
| vascular process in circulatory system |
| cardiac chamber development |
| positive regulation of vasculature development |
| epithelial cell development |
| anterior/posterior pattern specification |
| transcription regulatory region DNA binding |
| regulation of epithelial cell migration |
| mesenchyme development |
| connective tissue development |
| response to insulin |
| skeletal system morphogenesis |
| cell fate commitment |
| heart morphogenesis |
| regulation of animal organ morphogenesis |
| ossification |
| cellular response to peptide hormone stimulus |
| kidney development |
| nuclear body |
| renal system development |
| striated muscle tissue development |
| regulation of angiogenesis |
| embryonic organ morphogenesis |
| muscle organ development |
| muscle tissue development |
| epithelial tube morphogenesis |
| camera-type eye development |
| RNA polymerase II regulatory region sequence-specific DNA binding |
| angiogenesis |
| urogenital system development |
| regulation of vasculature development |
| cellular response to peptide |
| regulation of developmental growth |
| regionalization |
| extracellular matrix organization |
| eye development |
| visual system development |
| sensory system development |
| extracellular structure organization |
| developmental growth |
| blood circulation |
| response to peptide hormone |
| growth |
| circulatory system process |
| positive regulation of cell adhesion |
| blood vessel morphogenesis |
| sequence-specific DNA binding |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| supramolecular fiber organization |
| response to peptide |
| muscle structure development |
| blood vessel development |
| skeletal system development |
| positive regulation of cell migration |
| RNA polymerase II proximal promoter sequence-specific DNA binding |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| vasculature development |
| regulation of anatomical structure size |
| cardiovascular system development |
| positive regulation of cell motility |
| heart development |
| positive regulation of cellular component movement |
| sensory organ development |
| positive regulation of locomotion |
| cell population proliferation |
| tissue morphogenesis |
| embryonic morphogenesis |
| cellular response to organonitrogen compound |
| cellular response to hormone stimulus |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| cellular response to nitrogen compound |
| regulation of growth |
| DNA-binding transcription factor activity |
| regulation of cell adhesion |
| epithelial cell differentiation |
| enzyme linked receptor protein signaling pathway |
| tube development |
| regulation of cell migration |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| negative regulation of apoptotic process |
| anatomical structure formation involved in morphogenesis |
| negative regulation of programmed cell death |
| response to hormone |
| regulation of cell motility |
| negative regulation of developmental process |
| animal organ morphogenesis |
| embryo development |
| regulation of locomotion |
| regulation of cellular component movement |
| negative regulation of cell death |
| response to organonitrogen compound |
| cellular response to oxygen-containing compound |
| regulation of anatomical structure morphogenesis |
| identical protein binding |
| response to nitrogen compound |
| epithelium development |
| negative regulation of transcription, DNA-templated |
| negative regulation of multicellular organismal process |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of RNA metabolic process |
| positive regulation of developmental process |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| regulation of apoptotic process |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| regulation of programmed cell death |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| regulation of cell death |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| protein-containing complex subunit organization |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 6/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 1/1 |
| 909776.0 | 0/1 |
| bile duct | 1/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 2/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 1/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 4134
- Expression level (log2 read counts): -2.11
Expression Distribution
FOXC2 Expression in NALM6 Cells: -2.11
