FOXH1 [The Human Chemical-Genetic Interaction Map Project]

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======= FOXH1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FOXH1
  * **<color #00a2e8>Official Name</color>**: forkhead box H1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8928|8928]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75593|O75593]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FOXH1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FOXH1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603621|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). {ECO:0000269|PubMed:9702198}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fork head|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|embryonic heart tube anterior/posterior pattern specification|
|nodal signaling pathway involved in determination of left/right asymmetry|
|nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry|
|regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry|
|activin responsive factor complex|
|determination of left/right asymmetry in lateral mesoderm|
|axial mesoderm development|
|heart field specification|
|secondary heart field specification|
|nodal signaling pathway|
|co-SMAD binding|
|lateral mesoderm development|
|heart formation|
|negative regulation of intracellular estrogen receptor signaling pathway|
|specification of animal organ identity|
|enhancer binding|
|negative regulation of androgen receptor signaling pathway|
|ventricular trabecula myocardium morphogenesis|
|cardiac right ventricle morphogenesis|
|R-SMAD binding|
|activin receptor signaling pathway|
|bHLH transcription factor binding|
|regulation of androgen receptor signaling pathway|
|aorta morphogenesis|
|heart trabecula morphogenesis|
|animal organ formation|
|negative regulation of intracellular steroid hormone receptor signaling pathway|
|regulation of intracellular estrogen receptor signaling pathway|
|androgen receptor binding|
|trabecula morphogenesis|
|ventricular cardiac muscle tissue morphogenesis|
|aorta development|
|SMAD binding|
|ventricular cardiac muscle tissue development|
|heart looping|
|artery morphogenesis|
|determination of heart left/right asymmetry|
|embryonic heart tube morphogenesis|
|cardiac muscle tissue morphogenesis|
|outflow tract morphogenesis|
|cardiac ventricle morphogenesis|
|embryonic heart tube development|
|regulation of intracellular steroid hormone receptor signaling pathway|
|muscle tissue morphogenesis|
|artery development|
|muscle organ morphogenesis|
|transforming growth factor beta receptor signaling pathway|
|determination of left/right symmetry|
|determination of bilateral symmetry|
|mesoderm development|
|specification of symmetry|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|cellular response to transforming growth factor beta stimulus|
|negative regulation of DNA-binding transcription factor activity|
|cardiac muscle tissue development|
|response to transforming growth factor beta|
|cardiac chamber development|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|transcription factor complex|
|anterior/posterior pattern specification|
|transcription regulatory region DNA binding|
|mesenchyme development|
|nuclear chromatin|
|protein domain specific binding|
|heart morphogenesis|
|striated muscle tissue development|
|embryonic organ morphogenesis|
|muscle organ development|
|muscle tissue development|
|epithelial tube morphogenesis|
|regionalization|
|blood vessel morphogenesis|
|sequence-specific DNA binding|
|regulation of DNA-binding transcription factor activity|
|morphogenesis of an epithelium|
|embryonic organ development|
|pattern specification process|
|DNA-binding transcription activator activity, RNA polymerase II-specific|
|muscle structure development|
|blood vessel development|
|cellular response to growth factor stimulus|
|vasculature development|
|cardiovascular system development|
|heart development|
|response to growth factor|
|tissue morphogenesis|
|embryonic morphogenesis|
|tube morphogenesis|
|DNA-binding transcription factor activity|
|enzyme linked receptor protein signaling pathway|
|tube development|
|negative regulation of transcription by RNA polymerase II|
|circulatory system development|
|anatomical structure formation involved in morphogenesis|
|animal organ morphogenesis|
|embryo development|
|cellular response to cytokine stimulus|
|response to cytokine|
|epithelium development|
|negative regulation of molecular function|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|negative regulation of biosynthetic process|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.08|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10525
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.53 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FOXH1 Expression in NALM6 Cells: 1.53'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>