FOXH1
Gene Information
- Official Symbol: FOXH1
- Official Name: forkhead box H1
- Aliases and Previous Symbols: N/A
- Entrez ID: 8928
- UniProt: O75593
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. [provided by RefSeq, Jul 2008].
- UniProt Summary: Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element). {ECO:0000269|PubMed:9702198}.
Pfam Domains GO Terms
Pfam Domains
| Fork head |
GO Terms
| embryonic heart tube anterior/posterior pattern specification |
| nodal signaling pathway involved in determination of left/right asymmetry |
| nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry |
| regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry |
| activin responsive factor complex |
| determination of left/right asymmetry in lateral mesoderm |
| axial mesoderm development |
| heart field specification |
| secondary heart field specification |
| nodal signaling pathway |
| co-SMAD binding |
| lateral mesoderm development |
| heart formation |
| negative regulation of intracellular estrogen receptor signaling pathway |
| specification of animal organ identity |
| enhancer binding |
| negative regulation of androgen receptor signaling pathway |
| ventricular trabecula myocardium morphogenesis |
| cardiac right ventricle morphogenesis |
| R-SMAD binding |
| activin receptor signaling pathway |
| bHLH transcription factor binding |
| regulation of androgen receptor signaling pathway |
| aorta morphogenesis |
| heart trabecula morphogenesis |
| animal organ formation |
| negative regulation of intracellular steroid hormone receptor signaling pathway |
| regulation of intracellular estrogen receptor signaling pathway |
| androgen receptor binding |
| trabecula morphogenesis |
| ventricular cardiac muscle tissue morphogenesis |
| aorta development |
| SMAD binding |
| ventricular cardiac muscle tissue development |
| heart looping |
| artery morphogenesis |
| determination of heart left/right asymmetry |
| embryonic heart tube morphogenesis |
| cardiac muscle tissue morphogenesis |
| outflow tract morphogenesis |
| cardiac ventricle morphogenesis |
| embryonic heart tube development |
| regulation of intracellular steroid hormone receptor signaling pathway |
| muscle tissue morphogenesis |
| artery development |
| muscle organ morphogenesis |
| transforming growth factor beta receptor signaling pathway |
| determination of left/right symmetry |
| determination of bilateral symmetry |
| mesoderm development |
| specification of symmetry |
| cardiac chamber morphogenesis |
| cardiac ventricle development |
| cellular response to transforming growth factor beta stimulus |
| negative regulation of DNA-binding transcription factor activity |
| cardiac muscle tissue development |
| response to transforming growth factor beta |
| cardiac chamber development |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| transcription factor complex |
| anterior/posterior pattern specification |
| transcription regulatory region DNA binding |
| mesenchyme development |
| nuclear chromatin |
| protein domain specific binding |
| heart morphogenesis |
| striated muscle tissue development |
| embryonic organ morphogenesis |
| muscle organ development |
| muscle tissue development |
| epithelial tube morphogenesis |
| regionalization |
| blood vessel morphogenesis |
| sequence-specific DNA binding |
| regulation of DNA-binding transcription factor activity |
| morphogenesis of an epithelium |
| embryonic organ development |
| pattern specification process |
| DNA-binding transcription activator activity, RNA polymerase II-specific |
| muscle structure development |
| blood vessel development |
| cellular response to growth factor stimulus |
| vasculature development |
| cardiovascular system development |
| heart development |
| response to growth factor |
| tissue morphogenesis |
| embryonic morphogenesis |
| tube morphogenesis |
| DNA-binding transcription factor activity |
| enzyme linked receptor protein signaling pathway |
| tube development |
| negative regulation of transcription by RNA polymerase II |
| circulatory system development |
| anatomical structure formation involved in morphogenesis |
| animal organ morphogenesis |
| embryo development |
| cellular response to cytokine stimulus |
| response to cytokine |
| epithelium development |
| negative regulation of molecular function |
| negative regulation of transcription, DNA-templated |
| positive regulation of transcription by RNA polymerase II |
| cellular response to endogenous stimulus |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| negative regulation of signal transduction |
| negative regulation of RNA metabolic process |
| negative regulation of cell communication |
| negative regulation of signaling |
| negative regulation of cellular macromolecule biosynthetic process |
| negative regulation of nucleobase-containing compound metabolic process |
| DNA binding |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| DNA-binding transcription factor activity, RNA polymerase II-specific |
| negative regulation of response to stimulus |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| tissue development |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Mdivi-1 15μM R05 exp217 | 2.08 |
| Deguelin 0.15μM R05 exp209 | 2.18 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 10525
- Expression level (log2 read counts): 1.53
Expression Distribution
FOXH1 Expression in NALM6 Cells: 1.53
