FOXO4

Entrez Summary: This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010].
UniProt Summary: Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. {ECO:0000269|PubMed:10217147, ECO:0000269|PubMed:10783894, ECO:0000269|PubMed:12761217, ECO:0000269|PubMed:15126506, ECO:0000269|PubMed:16054032, ECO:0000269|PubMed:16964248, ECO:0000269|PubMed:20874444, ECO:0000269|PubMed:22972301}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

response to water-immersion restraint stress
negative regulation of smooth muscle cell differentiation
mitotic G2 DNA damage checkpoint
response to immobilization stress
mitotic G2/M transition checkpoint
G2 DNA damage checkpoint
regulation of smooth muscle cell differentiation
positive regulation of smooth muscle cell migration
negative regulation of G0 to G1 transition
regulation of G0 to G1 transition
promoter-specific chromatin binding
negative regulation of muscle cell differentiation
regulation of smooth muscle cell migration
positive regulation of cell cycle arrest
beta-catenin binding
insulin receptor signaling pathway
negative regulation of G2/M transition of mitotic cell cycle
mitotic DNA damage checkpoint
negative regulation of cell cycle G2/M phase transition
negative regulation of angiogenesis
mitotic DNA integrity checkpoint
negative regulation of blood vessel morphogenesis
regulation of cell cycle arrest
negative regulation of vasculature development
DNA damage checkpoint
DNA integrity checkpoint
cell cycle arrest
regulation of muscle cell differentiation
mitotic cell cycle checkpoint
stem cell differentiation
cellular response to insulin stimulus
glucose homeostasis
carbohydrate homeostasis
cell cycle checkpoint
regulation of G2/M transition of mitotic cell cycle
regulation of cell cycle G2/M phase transition
negative regulation of mitotic cell cycle phase transition
response to insulin
negative regulation of cell cycle phase transition
cellular response to peptide hormone stimulus