FPR1 [The Human Chemical-Genetic Interaction Map Project]

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======= FPR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FPR1
  * **<color #00a2e8>Official Name</color>**: formyl peptide receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2357|2357]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P21462|P21462]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FPR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FPR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/136537|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:1712023, PubMed:10514456). {ECO:0000269|PubMed:10514456, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:2161213, ECO:0000269|PubMed:2176894, ECO:0000303|PubMed:10514456, ECO:0000303|PubMed:1712023, ECO:0000303|PubMed:2161213, ECO:0000303|PubMed:2176894}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|scavenger receptor binding|
|N-formyl peptide receptor activity|
|RAGE receptor binding|
|complement receptor mediated signaling pathway|
|nitric oxide mediated signal transduction|
|azurophil granule membrane|
|ficolin-1-rich granule membrane|
|G protein-coupled receptor binding|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|secretory granule membrane|
|activation of MAPK activity|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|positive regulation of MAP kinase activity|
|positive regulation of cytosolic calcium ion concentration|
|regulation of cytosolic calcium ion concentration|
|activation of protein kinase activity|
|second-messenger-mediated signaling|
|positive regulation of protein serine/threonine kinase activity|
|regulation of MAP kinase activity|
|cellular calcium ion homeostasis|
|immune response-activating cell surface receptor signaling pathway|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|immune response-regulating cell surface receptor signaling pathway|
|neutrophil degranulation|
|divalent inorganic cation homeostasis|
|neutrophil activation involved in immune response|
|neutrophil mediated immunity|
|inflammatory response|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|regulation of protein serine/threonine kinase activity|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|chemotaxis|
|taxis|
|cellular metal ion homeostasis|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|myeloid leukocyte activation|
|immune response-regulating signaling pathway|
|metal ion homeostasis|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|activation of immune response|
|cellular cation homeostasis|
|cellular ion homeostasis|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|regulated exocytosis|
|cation homeostasis|
|inorganic ion homeostasis|
|G protein-coupled receptor activity|
|cellular chemical homeostasis|
|regulation of MAPK cascade|
|leukocyte mediated immunity|
|ion homeostasis|
|exocytosis|
|regulation of protein kinase activity|
|positive regulation of immune response|
|regulation of kinase activity|
|cellular homeostasis|
|leukocyte activation|
|regulation of transferase activity|
|secretion by cell|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|export from cell|
|positive regulation of phosphorylation|
|cell activation|
|immune effector process|
|response to cytokine|
|chemical homeostasis|
|secretion|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of protein modification process|
|locomotion|
|G protein-coupled receptor signaling pathway|
|defense response|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of protein metabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.99|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-1.85|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-1.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 8162
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.21 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FPR1 Expression in NALM6 Cells: 0.21'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>