FPR1

Gene Information

Official Symbol: FPR1
Official Name: formyl peptide receptor 1
Aliases and Previous Symbols: N/A
Entrez ID: 2357
UniProt: P21462
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010].
UniProt Summary: High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol- calcium second messenger system (PubMed:1712023, PubMed:10514456). {ECO:0000269|PubMed:10514456, ECO:0000269|PubMed:15153520, ECO:0000269|PubMed:2161213, ECO:0000269|PubMed:2176894, ECO:0000303|PubMed:10514456, ECO:0000303|PubMed:1712023, ECO:0000303|PubMed:2161213, ECO:0000303|PubMed:2176894}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 8162
Expression level (log2 read counts): 0.21

Expression Distribution

Screen	Score
Phorbol-12-myristate-13-acetate 0.57μM R08 exp514	-1.99
GSK-J4 1-1.25μM to day4 R07 exp363	-1.85
HMS-I1 1μM R01 exp46	-1.76

scavenger receptor binding
N-formyl peptide receptor activity
RAGE receptor binding
complement receptor mediated signaling pathway
nitric oxide mediated signal transduction
azurophil granule membrane
ficolin-1-rich granule membrane
G protein-coupled receptor binding
phospholipase C-activating G protein-coupled receptor signaling pathway
secretory granule membrane
activation of MAPK activity
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
positive regulation of MAP kinase activity
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
activation of protein kinase activity
second-messenger-mediated signaling
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
cellular calcium ion homeostasis
immune response-activating cell surface receptor signaling pathway
calcium ion homeostasis
cellular divalent inorganic cation homeostasis
immune response-regulating cell surface receptor signaling pathway
neutrophil degranulation
divalent inorganic cation homeostasis
neutrophil activation involved in immune response
neutrophil mediated immunity
inflammatory response
neutrophil activation
granulocyte activation
leukocyte degranulation
regulation of protein serine/threonine kinase activity
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
positive regulation of protein kinase activity
positive regulation of MAPK cascade
chemotaxis
taxis