FRAS1

Entrez Summary: This gene encodes an extracellular matrix protein that appears to function in the regulation of epidermal-basement membrane adhesion and organogenesis during development. Mutations in this gene cause Fraser syndrome, a multisystem malformation that can include craniofacial, urogenital and respiratory system abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

VWC
Calx-beta

metanephros morphogenesis
metanephros development
kidney morphogenesis
basement membrane
roof of mouth development
embryonic limb morphogenesis
embryonic appendage morphogenesis
extracellular matrix structural constituent
limb morphogenesis
appendage morphogenesis
appendage development
limb development
kidney development
renal system development
urogenital system development
collagen-containing extracellular matrix
skin development
morphogenesis of an epithelium
tissue morphogenesis
embryonic morphogenesis
animal organ morphogenesis
embryo development
epithelium development
protein transport
peptide transport
amide transport
establishment of protein localization
tissue development
nitrogen compound transport