FUT1

Entrez Summary: This gene encodes a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the synthesis of soluble A and B antigens. This is one of two genes encoding the galactoside 2-L-fucosyltransferase enzyme. Mutations in this gene are a cause of the H-Bombay blood group. [provided by RefSeq, Aug 2016].
UniProt Summary: Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Gal-beta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. {ECO:0000269|PubMed:2118655}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

galactoside 2-alpha-L-fucosyltransferase activity
L-fucose catabolic process
fucosyltransferase activity
fucose catabolic process
L-fucose metabolic process
fucose metabolic process
fucosylation
hexose catabolic process
monosaccharide catabolic process
Golgi cisterna membrane
carbohydrate catabolic process
hexose metabolic process
monosaccharide metabolic process
protein glycosylation
macromolecule glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
small molecule catabolic process
carbohydrate metabolic process
carbohydrate derivative biosynthetic process
Golgi apparatus
carbohydrate derivative metabolic process
integral component of plasma membrane
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
small molecule metabolic process
macromolecule biosynthetic process
organic substance catabolic process
membrane