FUZ [The Human Chemical-Genetic Interaction Map Project]

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======= FUZ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: FUZ
  * **<color #00a2e8>Official Name</color>**: fuzzy planar cell polarity protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80199|80199]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BT04|Q9BT04]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=FUZ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20FUZ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610622|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associated with neural tube defects in humans. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity). {ECO:0000250|UniProtKB:Q3UYI6}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of neural crest formation|
|negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation|
|negative regulation of neural crest formation|
|regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation|
|embryonic body morphogenesis|
|negative regulation of fibroblast growth factor receptor signaling pathway|
|establishment of tissue polarity|
|establishment of planar polarity|
|positive regulation of cilium assembly|
|negative regulation of embryonic development|
|negative regulation of epithelial to mesenchymal transition|
|regulation of fibroblast growth factor receptor signaling pathway|
|morphogenesis of a polarized epithelium|
|non-motile cilium assembly|
|body morphogenesis|
|hair follicle development|
|skin epidermis development|
|positive regulation of organelle assembly|
|hair cycle process|
|molting cycle process|
|regulation of smoothened signaling pathway|
|regulation of cilium assembly|
|regulation of epithelial to mesenchymal transition|
|neural tube closure|
|hair cycle|
|molting cycle|
|tube closure|
|embryonic skeletal system morphogenesis|
|cell projection|
|primary neural tube formation|
|positive regulation of plasma membrane bounded cell projection assembly|
|neural tube formation|
|embryonic epithelial tube formation|
|embryonic skeletal system development|
|regulation of embryonic development|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|tube formation|
|negative regulation of cellular response to growth factor stimulus|
|neural tube development|
|negative regulation of canonical Wnt signaling pathway|
|regulation of plasma membrane bounded cell projection assembly|
|regulation of cell projection assembly|
|negative regulation of Wnt signaling pathway|
|regulation of organelle assembly|
|skeletal system morphogenesis|
|negative regulation of cell migration|
|regulation of cellular response to growth factor stimulus|
|negative regulation of cell motility|
|regulation of canonical Wnt signaling pathway|
|embryonic organ morphogenesis|
|epithelial tube morphogenesis|
|negative regulation of cellular component movement|
|negative regulation of locomotion|
|cilium assembly|
|regulation of Wnt signaling pathway|
|cytoskeleton|
|cilium organization|
|positive regulation of cell projection organization|
|skin development|
|epidermis development|
|morphogenesis of an epithelium|
|embryonic organ development|
|plasma membrane bounded cell projection assembly|
|cell projection assembly|
|skeletal system development|
|positive regulation of cellular component biogenesis|
|tissue morphogenesis|
|embryonic morphogenesis|
|positive regulation of organelle organization|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|negative regulation of cell population proliferation|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|negative regulation of cell differentiation|
|organelle assembly|
|tube development|
|regulation of cell migration|
|anatomical structure formation involved in morphogenesis|
|regulation of cell motility|
|negative regulation of developmental process|
|animal organ morphogenesis|
|regulation of cellular component biogenesis|
|embryo development|
|regulation of locomotion|
|regulation of cellular component movement|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of cellular component organization|
|negative regulation of signal transduction|
|regulation of organelle organization|
|negative regulation of cell communication|
|negative regulation of signaling|
|protein transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|tissue development|
|regulation of cell differentiation|
|nitrogen compound transport|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9685
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.44 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='FUZ Expression in NALM6 Cells: 2.44'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>