FUZ

Gene Information

Official Symbol: FUZ
Official Name: fuzzy planar cell polarity protein
Aliases and Previous Symbols: N/A
Entrez ID: 80199
UniProt: Q9BT04
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associated with neural tube defects in humans. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012].
UniProt Summary: Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies. May regulate the morphogenesis of hair follicles which depends on functional primary cilia (By similarity). {ECO:0000250|UniProtKB:Q3UYI6}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9685
Expression level (log2 read counts): 2.44

Expression Distribution

regulation of neural crest formation
negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
negative regulation of neural crest formation
regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation
embryonic body morphogenesis
negative regulation of fibroblast growth factor receptor signaling pathway
establishment of tissue polarity
establishment of planar polarity
positive regulation of cilium assembly
negative regulation of embryonic development
negative regulation of epithelial to mesenchymal transition
regulation of fibroblast growth factor receptor signaling pathway
morphogenesis of a polarized epithelium
non-motile cilium assembly
body morphogenesis
hair follicle development
skin epidermis development
positive regulation of organelle assembly
hair cycle process
molting cycle process
regulation of smoothened signaling pathway
regulation of cilium assembly
regulation of epithelial to mesenchymal transition
neural tube closure
hair cycle
molting cycle
tube closure
embryonic skeletal system morphogenesis
cell projection
primary neural tube formation
positive regulation of plasma membrane bounded cell projection assembly
neural tube formation
embryonic epithelial tube formation
embryonic skeletal system development
regulation of embryonic development
epithelial tube formation
morphogenesis of embryonic epithelium
tube formation
negative regulation of cellular response to growth factor stimulus
neural tube development