FXR2

Entrez Summary: The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X cognitive disability syndrome. [provided by RefSeq, Jul 2008].
UniProt Summary: RNA-binding protein.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ribonucleoprotein granule
translation regulator activity
polysome
cytosolic large ribosomal subunit
cytoplasmic ribonucleoprotein granule
mRNA 3-UTR binding
positive regulation of translation
negative regulation of translation
negative regulation of cellular amide metabolic process
dendritic spine
positive regulation of cellular amide metabolic process
mRNA binding
regulation of mRNA stability
regulation of RNA stability
regulation of mRNA catabolic process
postsynaptic density
axon
regulation of mRNA metabolic process
regulation of translation
neuronal cell body
regulation of cellular amide metabolic process
protein heterodimerization activity
posttranscriptional regulation of gene expression
regulation of cellular catabolic process
protein homodimerization activity
regulation of catabolic process
negative regulation of cellular protein metabolic process
identical protein binding
negative regulation of protein metabolic process
negative regulation of cellular macromolecule biosynthetic process
RNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
positive regulation of cellular protein metabolic process
positive regulation of protein metabolic process
negative regulation of gene expression
positive regulation of macromolecule biosynthetic process
positive regulation of cellular biosynthetic process
positive regulation of gene expression