FXYD2

Entrez Summary: This gene encodes a member of the FXYD family of transmembrane proteins. This particular protein encodes the sodium/potassium-transporting ATPase subunit gamma. Mutations in this gene have been associated with Renal Hypomagnesemia-2. Alternatively spliced transcript variants have been described. Read-through transcripts have been observed between this locus and the upstream FXYD domain-containing ion transport regulator 6 (FXYD6, GeneID 53826) locus.[provided by RefSeq, Feb 2011].
UniProt Summary: May be involved in forming the receptor site for cardiac glycoside binding or may modulate the transport function of the sodium ATPase.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ion channel regulator activity
sodium:potassium-exchanging ATPase activity
sodium:potassium-exchanging ATPase complex
sodium ion export across plasma membrane
establishment or maintenance of transmembrane electrochemical gradient
sodium channel regulator activity
export across plasma membrane
transporter activity
potassium ion import across plasma membrane
regulation of sodium ion transmembrane transporter activity
regulation of sodium ion transmembrane transport
regulation of cardiac conduction
inorganic cation import across plasma membrane
inorganic ion import across plasma membrane
regulation of sodium ion transport
sodium ion transmembrane transport
import across plasma membrane
sodium ion transport
potassium ion transmembrane transport
potassium ion transport
regulation of heart contraction
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
regulation of transporter activity
regulation of blood circulation
regulation of cation transmembrane transport
regulation of metal ion transport
monovalent inorganic cation transport
regulation of ion transmembrane transport
inorganic cation transmembrane transport
regulation of transmembrane transport
regulation of system process
cation transmembrane transport
metal ion transport
inorganic ion transmembrane transport
import into cell
regulation of ion transport
cation transport
ion transmembrane transport
export from cell