FYCO1

Entrez Summary: This gene encodes a protein that contains a RUN domain, FYVE-type zinc finger domain and Golgi dynamics (GOLD) domain. The encoded protein plays a role in microtubule plus end-directed transport of autophagic vesicles through interactions with the small GTPase Rab7, phosphatidylinositol-3-phosphate (PI3P) and the autophagosome marker LC3. Mutations in this gene are a cause of autosomal recessive congenital cataract-2 (CATC2). [provided by RefSeq, Dec 2011].
UniProt Summary: May mediate microtubule plus end-directed vesicle transport. {ECO:0000269|PubMed:20100911}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Nocodazole 0.02μM R00 exp23	-1.9
MS023 7μM R03 exp135	-1.88

FYVE
RUN

plus-end-directed vesicle transport along microtubule
positive regulation of autophagosome maturation
plus-end-directed organelle transport along microtubule
regulation of autophagosome maturation
positive regulation of protein complex disassembly
vesicle transport along microtubule
vesicle cytoskeletal trafficking
positive regulation of macroautophagy
autophagosome
organelle transport along microtubule
regulation of protein complex disassembly
positive regulation of autophagy
late endosome
transport along microtubule
regulation of macroautophagy
establishment of vesicle localization
cytoskeleton-dependent intracellular transport
microtubule-based transport
vesicle localization
lysosome
microtubule-based movement
regulation of autophagy
establishment of organelle localization
positive regulation of cellular catabolic process
positive regulation of catabolic process
organelle localization
positive regulation of organelle organization
microtubule-based process
intracellular membrane-bounded organelle
regulation of cellular catabolic process
Golgi apparatus
regulation of catabolic process
positive regulation of cellular component organization
regulation of organelle organization
intracellular transport
movement of cell or subcellular component
establishment of localization in cell
membrane