FZD10

Gene Information

Official Symbol: FZD10
Official Name: frizzled class receptor 10
Aliases and Previous Symbols: N/A
Entrez ID: 11211
UniProt: Q9ULW2
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for Wnt proteins. Functions in the canonical Wnt/beta-catenin signaling pathway (By similarity). The canonical Wnt/beta-catenin signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues (Probable). {ECO:0000250|UniProtKB:Q8BKG4, ECO:0000305}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 10825
Expression level (log2 read counts): -3.21

Expression Distribution

Frizzled
Fz

non-canonical Wnt signaling pathway via JNK cascade
non-canonical Wnt signaling pathway via MAPK cascade
Wnt-activated receptor activity
Wnt-protein binding
negative regulation of GTPase activity
cellular response to retinoic acid
positive regulation of JUN kinase activity
regulation of JUN kinase activity
canonical Wnt signaling pathway
response to retinoic acid
non-canonical Wnt signaling pathway
positive regulation of JNK cascade
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
regulation of JNK cascade
cellular response to acid chemical
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
positive regulation of MAP kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
regulation of actin cytoskeleton organization
response to acid chemical
cell-cell signaling by wnt
Wnt signaling pathway
regulation of actin filament-based process
positive regulation of GTPase activity
cell surface receptor signaling pathway involved in cell-cell signaling
negative regulation of hydrolase activity
regulation of GTPase activity
regulation of protein serine/threonine kinase activity
cellular response to lipid
positive regulation of protein kinase activity
regulation of cytoskeleton organization
positive regulation of MAPK cascade
positive regulation of kinase activity
cell surface
positive regulation of transferase activity
G protein-coupled receptor activity
regulation of cellular response to stress