G3BP2 [The Human Chemical-Genetic Interaction Map Project]

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======= G3BP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: G3BP2
  * **<color #00a2e8>Official Name</color>**: G3BP stress granule assembly factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9908|9908]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UN86|Q9UN86]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=G3BP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20G3BP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/620020|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Probable scaffold protein that may be involved in mRNA transport. {ECO:0000305}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|NTF2|
|RRM 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of stress granule assembly|
|regulation of stress granule assembly|
|cytoplasmic sequestering of NF-kappaB|
|stress granule assembly|
|cytoplasmic sequestering of transcription factor|
|receptor signaling complex adaptor activity|
|cytoplasmic sequestering of protein|
|cytoplasmic stress granule|
|positive regulation of organelle assembly|
|negative regulation of NF-kappaB transcription factor activity|
|maintenance of protein location|
|mRNA transport|
|ribonucleoprotein complex|
|negative regulation of DNA-binding transcription factor activity|
|mRNA binding|
|maintenance of location|
|nucleic acid transport|
|RNA transport|
|establishment of RNA localization|
|RNA localization|
|regulation of organelle assembly|
|ribonucleoprotein complex assembly|
|nucleobase-containing compound transport|
|ribonucleoprotein complex subunit organization|
|Ras protein signal transduction|
|positive regulation of protein complex assembly|
|small GTPase mediated signal transduction|
|protein homooligomerization|
|regulation of DNA-binding transcription factor activity|
|regulation of protein complex assembly|
|ribonucleoprotein complex biogenesis|
|protein complex oligomerization|
|positive regulation of cellular component biogenesis|
|positive regulation of organelle organization|
|viral process|
|organelle assembly|
|innate immune response|
|symbiotic process|
|interspecies interaction between organisms|
|cellular protein-containing complex assembly|
|defense response to other organism|
|regulation of cellular component biogenesis|
|negative regulation of molecular function|
|positive regulation of cellular component organization|
|regulation of organelle organization|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|RNA binding|
|protein-containing complex assembly|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of cell communication|
|positive regulation of signaling|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.07|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.89|
|[[:results:exp208|Vinblastine 0.015μM R05 exp208]]|-1.87|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|-1.77|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.71|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|2.07|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|2.29|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5056
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.67 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='G3BP2 Expression in NALM6 Cells: 7.67'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>