G6PC2

Entrez Summary: This gene encodes an enzyme belonging to the glucose-6-phosphatase catalytic subunit family. These enzymes are part of a multicomponent integral membrane system that catalyzes the hydrolysis of glucose-6-phosphate, the terminal step in gluconeogenic and glycogenolytic pathways, allowing the release of glucose into the bloodstream. The family member encoded by this gene is found in pancreatic islets and does not exhibit phosphohydrolase activity, but it is a major target of cell-mediated autoimmunity in diabetes. Several alternatively spliced transcript variants of this gene have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008].
UniProt Summary: May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glucose-6-phosphatase activity
glucose 6-phosphate metabolic process
gluconeogenesis
hexose biosynthetic process
monosaccharide biosynthetic process
glucose metabolic process
carbohydrate biosynthetic process
hexose metabolic process
regulation of insulin secretion
glucose homeostasis
carbohydrate homeostasis
monosaccharide metabolic process
regulation of peptide hormone secretion
regulation of hormone secretion
dephosphorylation
regulation of protein secretion
carbohydrate metabolic process
regulation of peptide secretion
regulation of hormone levels
small molecule biosynthetic process
regulation of protein transport
regulation of peptide transport
regulation of establishment of protein localization
regulation of secretion by cell
regulation of secretion
organophosphate metabolic process
endoplasmic reticulum membrane
regulation of protein localization
carbohydrate derivative metabolic process
chemical homeostasis
homeostatic process
small molecule metabolic process
regulation of transport