GABBR1

Entrez Summary: This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA(B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jan 2016].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

G protein-coupled neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential
G protein-coupled GABA receptor activity
G protein-coupled receptor heterodimeric complex
neuron-glial cell signaling
gamma-aminobutyric acid signaling pathway
GABA-ergic synapse
presynaptic membrane
Schaffer collateral - CA1 synapse
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway
regulation of postsynaptic membrane potential
postsynaptic membrane
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
dendrite
regulation of membrane potential
cell junction
cell-cell signaling
G protein-coupled receptor signaling pathway
integral component of plasma membrane
extracellular region