GABRA6

Entrez Summary: N/A
UniProt Summary: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Neur chan memb
Neur chan LBD

cerebellar Golgi cell to granule cell synapse
inhibitory extracellular ligand-gated ion channel activity
benzodiazepine receptor activity
GABA-gated chloride ion channel activity
synaptic transmission, GABAergic
GABA-A receptor complex
GABA-A receptor activity
gamma-aminobutyric acid signaling pathway
dendrite membrane
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
chloride channel complex
extracellular ligand-gated ion channel activity
chloride channel activity
postsynapse
chloride transmembrane transport
regulation of postsynaptic membrane potential
chloride transport
inorganic anion transmembrane transport
inorganic anion transport
postsynaptic membrane
synapse
anion transmembrane transport
neuron projection
chemical synaptic transmission
anterograde trans-synaptic signaling
regulation of membrane potential
trans-synaptic signaling
synaptic signaling
cell junction
anion transport
inorganic ion transmembrane transport
ion transmembrane transport
cell-cell signaling
transmembrane transport
G protein-coupled receptor signaling pathway
ion transport
nervous system process
integral component of plasma membrane
system process