GAD1

Entrez Summary: This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. The enzyme encoded is responsible for catalyzing the production of gamma-aminobutyric acid from L-glutamic acid. A pathogenic role for this enzyme has been identified in the human pancreas since it has been identified as an autoantigen and an autoreactive T cell target in insulin-dependent diabetes. This gene may also play a role in the stiff man syndrome. Deficiency in this enzyme has been shown to lead to pyridoxine dependency with seizures. Alternative splicing of this gene results in two products, the predominant 67-kD form and a less-frequent 25-kD form. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the production of GABA.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Bisphenol A 100μM R06 exp269	-1.79
Citral 50μM R06 exp274	-1.76

glutamate decarboxylase activity
protein-pyridoxal-5-phosphate linkage
glutamate decarboxylation to succinate
gamma-aminobutyric acid biosynthetic process
gamma-aminobutyric acid metabolic process
glutamate catabolic process
clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
glutamate binding
protein-cofactor linkage
locomotory exploration behavior
inhibitory synapse
dicarboxylic acid catabolic process
glutamine family amino acid catabolic process
exploration behavior
vesicle membrane
glutamate metabolic process
presynaptic active zone
neurotransmitter biosynthetic process
axon terminus
intraspecies interaction between organisms
social behavior
pyridoxal phosphate binding
multi-organism behavior
glutamine family amino acid metabolic process
cellular amino acid biosynthetic process
neurotransmitter metabolic process
dicarboxylic acid metabolic process
neurotransmitter secretion
signal release from synapse
alpha-amino acid catabolic process
protein N-terminus binding
cellular amino acid catabolic process
cell cortex
signal release
neurotransmitter transport
monocarboxylic acid biosynthetic process
locomotory behavior
alpha-amino acid metabolic process
organic acid catabolic process
carboxylic acid catabolic process