GADD45B

Gene Information

Official Symbol: GADD45B
Official Name: growth arrest and DNA damage inducible beta
Aliases and Previous Symbols: N/A
Entrez ID: 4616
UniProt: O75293
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in the regulation of growth and apoptosis. Mediates activation of stress-responsive MTK1/MEKK4 MAPKKK.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3584
Expression level (log2 read counts): 2.72

Expression Distribution

activation of MAPKKK activity
positive regulation of p38MAPK cascade
regulation of p38MAPK cascade
activation of MAPKK activity
positive regulation of JNK cascade
positive regulation of stress-activated MAPK cascade
positive regulation of stress-activated protein kinase signaling cascade
regulation of JNK cascade
negative regulation of protein kinase activity
regulation of stress-activated MAPK cascade
regulation of stress-activated protein kinase signaling cascade
negative regulation of kinase activity
positive regulation of MAP kinase activity
negative regulation of transferase activity
activation of protein kinase activity
positive regulation of protein serine/threonine kinase activity
regulation of MAP kinase activity
negative regulation of protein phosphorylation
negative regulation of phosphorylation
regulation of protein serine/threonine kinase activity
positive regulation of protein kinase activity
positive regulation of MAPK cascade
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
positive regulation of kinase activity
negative regulation of protein modification process
positive regulation of apoptotic process
positive regulation of programmed cell death
positive regulation of transferase activity
positive regulation of cell death
regulation of cellular response to stress
regulation of MAPK cascade
negative regulation of catalytic activity
regulation of protein kinase activity
regulation of kinase activity
apoptotic process
regulation of transferase activity
positive regulation of protein phosphorylation
positive regulation of intracellular signal transduction
negative regulation of cellular protein metabolic process