GALNS

Entrez Summary: This gene encodes N-acetylgalactosamine-6-sulfatase which is a lysosomal exohydrolase required for the degradation of the glycosaminoglycans, keratan sulfate, and chondroitin 6-sulfate. Sequence alterations including point, missense and nonsense mutations, as well as those that affect splicing, result in a deficiency of this enzyme. Deficiencies of this enzyme lead to Morquio A syndrome, a lysosomal storage disorder. [provided by RefSeq, Jul 2008].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Phosphodiest
Sulfatase

N-acetylgalactosamine-6-sulfatase activity
N-acetylgalactosamine-4-sulfatase activity
sulfuric ester hydrolase activity
keratan sulfate catabolic process
arylsulfatase activity
keratan sulfate metabolic process
sulfur compound catabolic process
glycosaminoglycan catabolic process
aminoglycan catabolic process
azurophil granule lumen
lysosomal lumen
mucopolysaccharide metabolic process
glycosaminoglycan metabolic process
aminoglycan metabolic process
carbohydrate derivative catabolic process
sulfur compound metabolic process
neutrophil degranulation
neutrophil activation involved in immune response
neutrophil mediated immunity
neutrophil activation
granulocyte activation
leukocyte degranulation
myeloid leukocyte mediated immunity
myeloid cell activation involved in immune response
myeloid leukocyte activation
leukocyte activation involved in immune response
cell activation involved in immune response
regulated exocytosis
leukocyte mediated immunity
exocytosis
leukocyte activation
oxoacid metabolic process
secretion by cell
organic acid metabolic process
carbohydrate derivative metabolic process
export from cell
macromolecule catabolic process
organonitrogen compound catabolic process
cell activation
immune effector process