GALR1 [The Human Chemical-Genetic Interaction Map Project]

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======= GALR1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GALR1
  * **<color #00a2e8>Official Name</color>**: galanin receptor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2587|2587]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P47211|P47211]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GALR1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GALR1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600377|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family.  GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. {ECO:0000269|PubMed:25691535, ECO:0000269|PubMed:7524088}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7TM GPCR Srw|
|7tm 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cortisol secretion|
|positive regulation of glucocorticoid secretion|
|regulation of cortisol secretion|
|positive regulation of corticosteroid hormone secretion|
|galanin receptor activity|
|positive regulation of steroid hormone secretion|
|regulation of glucocorticoid secretion|
|regulation of corticosteroid hormone secretion|
|negative regulation of adenylate cyclase activity|
|regulation of steroid hormone secretion|
|negative regulation of cyclase activity|
|neuropeptide binding|
|negative regulation of lyase activity|
|regulation of adenylate cyclase activity|
|positive regulation of response to drug|
|peptide hormone binding|
|G protein-coupled peptide receptor activity|
|regulation of cyclase activity|
|regulation of endocrine process|
|regulation of lyase activity|
|positive regulation of lipid transport|
|positive regulation of lipid localization|
|regulation of response to drug|
|neuropeptide signaling pathway|
|regulation of lipid transport|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|positive regulation of hormone secretion|
|regulation of lipid localization|
|cAMP-mediated signaling|
|cyclic-nucleotide-mediated signaling|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|regulation of hormone secretion|
|positive regulation of cytosolic calcium ion concentration|
|regulation of cytosolic calcium ion concentration|
|second-messenger-mediated signaling|
|positive regulation of secretion by cell|
|positive regulation of secretion|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|cellular divalent inorganic cation homeostasis|
|divalent inorganic cation homeostasis|
|regulation of hormone levels|
|cellular metal ion homeostasis|
|regulation of system process|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|regulation of secretion by cell|
|ion homeostasis|
|negative regulation of catalytic activity|
|regulation of secretion|
|cellular homeostasis|
|positive regulation of transport|
|chemical homeostasis|
|negative regulation of molecular function|
|positive regulation of transcription by RNA polymerase II|
|G protein-coupled receptor signaling pathway|
|integral component of plasma membrane|
|positive regulation of transcription, DNA-templated|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|intracellular signal transduction|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|-1.87|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|-1.7|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|1.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4962
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.47 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GALR1 Expression in NALM6 Cells: 2.47'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>