GALR1

Gene Information

Official Symbol: GALR1
Official Name: galanin receptor 1
Aliases and Previous Symbols: N/A
Entrez ID: 2587
UniProt: P47211
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The neuropeptide galanin elicits a range of biological effects by interaction with specific G-protein-coupled receptors. Galanin receptors are seven-transmembrane proteins shown to activate a variety of intracellular second-messenger pathways. GALR1 inhibits adenylyl cyclase via a G protein of the Gi/Go family. GALR1 is widely expressed in the brain and spinal cord, as well as in peripheral sites such as the small intestine and heart. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for the hormone galanin. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. {ECO:0000269|PubMed:25691535, ECO:0000269|PubMed:7524088}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 4962
Expression level (log2 read counts): 2.47

Expression Distribution

Screen	Score
Ribavirin 10 to 15μM on day4 R04 exp160	-1.87
ABT-702 5μM R07 exp318	-1.7
HMS-I1 1μM R01 exp46	1.77

7TM GPCR Srw
7tm 1

positive regulation of cortisol secretion
positive regulation of glucocorticoid secretion
regulation of cortisol secretion
positive regulation of corticosteroid hormone secretion
galanin receptor activity
positive regulation of steroid hormone secretion
regulation of glucocorticoid secretion
regulation of corticosteroid hormone secretion
negative regulation of adenylate cyclase activity
regulation of steroid hormone secretion
negative regulation of cyclase activity
neuropeptide binding
negative regulation of lyase activity
regulation of adenylate cyclase activity
positive regulation of response to drug
peptide hormone binding
G protein-coupled peptide receptor activity
regulation of cyclase activity
regulation of endocrine process
regulation of lyase activity
positive regulation of lipid transport
positive regulation of lipid localization
regulation of response to drug
neuropeptide signaling pathway
regulation of lipid transport
adenylate cyclase-activating G protein-coupled receptor signaling pathway
positive regulation of hormone secretion
regulation of lipid localization
cAMP-mediated signaling
cyclic-nucleotide-mediated signaling
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
regulation of hormone secretion
positive regulation of cytosolic calcium ion concentration
regulation of cytosolic calcium ion concentration
second-messenger-mediated signaling
positive regulation of secretion by cell
positive regulation of secretion
cellular calcium ion homeostasis
calcium ion homeostasis