GALR2 [The Human Chemical-Genetic Interaction Map Project]

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======= GALR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GALR2
  * **<color #00a2e8>Official Name</color>**: galanin receptor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8811|8811]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O43603|O43603]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GALR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GALR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603691|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). {ECO:0000269|PubMed:24517231, ECO:0000269|PubMed:25691535, ECO:0000269|PubMed:9480833, ECO:0000269|PubMed:9685625, ECO:0000269|PubMed:9832121, ECO:0000269|PubMed:9880084}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|7tm 1|
|7TM GPCR Srsx|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of large conductance calcium-activated potassium channel activity|
|galanin-activated signaling pathway|
|regulation of large conductance calcium-activated potassium channel activity|
|galanin receptor activity|
|negative regulation of adenylate cyclase activity|
|negative regulation of cyclase activity|
|negative regulation of lyase activity|
|neuropeptide binding|
|positive regulation of potassium ion transmembrane transporter activity|
|regulation of adenylate cyclase activity|
|positive regulation of potassium ion transmembrane transport|
|G protein-coupled peptide receptor activity|
|peptide hormone binding|
|regulation of cyclase activity|
|positive regulation of potassium ion transport|
|regulation of lyase activity|
|regulation of potassium ion transmembrane transporter activity|
|inositol phosphate metabolic process|
|positive regulation of cation channel activity|
|regulation of potassium ion transmembrane transport|
|feeding behavior|
|phospholipase C-activating G protein-coupled receptor signaling pathway|
|regulation of potassium ion transport|
|positive regulation of ion transmembrane transporter activity|
|neuropeptide signaling pathway|
|polyol metabolic process|
|positive regulation of transporter activity|
|adenylate cyclase-activating G protein-coupled receptor signaling pathway|
|positive regulation of cation transmembrane transport|
|cAMP-mediated signaling|
|positive regulation of ion transmembrane transport|
|phosphatidylinositol metabolic process|
|regulation of cation channel activity|
|cyclic-nucleotide-mediated signaling|
|cilium|
|positive regulation of transmembrane transport|
|adenylate cyclase-modulating G protein-coupled receptor signaling pathway|
|G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger|
|muscle contraction|
|regulation of ion transmembrane transporter activity|
|learning or memory|
|regulation of transmembrane transporter activity|
|positive regulation of ion transport|
|regulation of transporter activity|
|positive regulation of cytosolic calcium ion concentration|
|cognition|
|muscle system process|
|glycerophospholipid metabolic process|
|alcohol metabolic process|
|regulation of cytosolic calcium ion concentration|
|regulation of cation transmembrane transport|
|second-messenger-mediated signaling|
|phospholipid metabolic process|
|glycerolipid metabolic process|
|regulation of metal ion transport|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|organic hydroxy compound metabolic process|
|cellular divalent inorganic cation homeostasis|
|regulation of ion transmembrane transport|
|divalent inorganic cation homeostasis|
|cellular metal ion homeostasis|
|regulation of transmembrane transport|
|behavior|
|metal ion homeostasis|
|cellular cation homeostasis|
|cellular ion homeostasis|
|neuron projection development|
|regulation of ion transport|
|cation homeostasis|
|inorganic ion homeostasis|
|cellular chemical homeostasis|
|ion homeostasis|
|negative regulation of catalytic activity|
|neuron development|
|organophosphate metabolic process|
|cellular homeostasis|
|cellular lipid metabolic process|
|positive regulation of transport|
|neuron differentiation|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|G protein-coupled receptor signaling pathway|
|nervous system process|
|integral component of plasma membrane|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|cell development|
|intracellular signal transduction|
|positive regulation of RNA metabolic process|
|small molecule metabolic process|
|positive regulation of molecular function|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.89|
|[[:results:exp333|All-trans-Retinoic-Acid 8μM R07 exp333]]|-1.72|
|[[:results:exp151|SGC0946 7μM R03 exp151]]|-1.71|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15922
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GALR2 Expression in NALM6 Cells: -2.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>