GALR2

Gene Information

Official Symbol: GALR2
Official Name: galanin receptor 2
Aliases and Previous Symbols: N/A
Entrez ID: 8811
UniProt: O43603
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Receptor for the hormone galanin and GALP. Receptor for the hormone spexin-1 (PubMed:24517231). The activity of this receptor is mediated by G proteins that activate the phospholipase C/protein kinase C pathway (via G(q)) and that inhibit adenylyl cyclase (via G(i)). {ECO:0000269|PubMed:24517231, ECO:0000269|PubMed:25691535, ECO:0000269|PubMed:9480833, ECO:0000269|PubMed:9685625, ECO:0000269|PubMed:9832121, ECO:0000269|PubMed:9880084}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15922
Expression level (log2 read counts): -2.84

Expression Distribution

Screen	Score
Adefovir 20μM R07 exp332	-1.89
All-trans-Retinoic-Acid 8μM R07 exp333	-1.72
SGC0946 7μM R03 exp151	-1.71

7tm 1
7TM GPCR Srsx

positive regulation of large conductance calcium-activated potassium channel activity
galanin-activated signaling pathway
regulation of large conductance calcium-activated potassium channel activity
galanin receptor activity
negative regulation of adenylate cyclase activity
negative regulation of cyclase activity
negative regulation of lyase activity
neuropeptide binding
positive regulation of potassium ion transmembrane transporter activity
regulation of adenylate cyclase activity
positive regulation of potassium ion transmembrane transport
G protein-coupled peptide receptor activity
peptide hormone binding
regulation of cyclase activity
positive regulation of potassium ion transport
regulation of lyase activity
regulation of potassium ion transmembrane transporter activity
inositol phosphate metabolic process
positive regulation of cation channel activity
regulation of potassium ion transmembrane transport
feeding behavior
phospholipase C-activating G protein-coupled receptor signaling pathway
regulation of potassium ion transport
positive regulation of ion transmembrane transporter activity
neuropeptide signaling pathway
polyol metabolic process
positive regulation of transporter activity
adenylate cyclase-activating G protein-coupled receptor signaling pathway
positive regulation of cation transmembrane transport
cAMP-mediated signaling
positive regulation of ion transmembrane transport
phosphatidylinositol metabolic process
regulation of cation channel activity
cyclic-nucleotide-mediated signaling
cilium
positive regulation of transmembrane transport
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
muscle contraction
regulation of ion transmembrane transporter activity