GALT

Entrez Summary: Galactose-1-phosphate uridyl transferase (GALT) catalyzes the second step of the Leloir pathway of galactose metabolism, namely the conversion of UDP-glucose + galactose-1-phosphate to glucose-1-phosphate + UDP-galactose. The absence of this enzyme results in classic galactosemia in humans and can be fatal in the newborn period if lactose is not removed from the diet. The pathophysiology of galactosemia has not been clearly defined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GalP UDP transf
GalP UDP tr C

UDP-glucose:hexose-1-phosphate uridylyltransferase activity
UDP-glucose catabolic process
nucleotide-sugar catabolic process
UDP-glucose metabolic process
galactose catabolic process via UDP-galactose
galactose catabolic process
galactose metabolic process
nucleotide-sugar metabolic process
nucleobase-containing small molecule catabolic process
hexose catabolic process
monosaccharide catabolic process
carbohydrate catabolic process
hexose metabolic process
carbohydrate derivative catabolic process
monosaccharide metabolic process
nucleobase-containing compound catabolic process
heterocycle catabolic process
cellular nitrogen compound catabolic process
small molecule catabolic process
aromatic compound catabolic process
carbohydrate metabolic process
organic cyclic compound catabolic process
nucleobase-containing small molecule metabolic process
zinc ion binding
Golgi apparatus
carbohydrate derivative metabolic process
small molecule metabolic process
organic substance catabolic process
cellular catabolic process