GAPT

Entrez Summary: N/A
UniProt Summary: Negatively regulates B-cell proliferation following stimulation through the B-cell receptor. May play an important role in maintenance of marginal zone (MZ) B-cells (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	1/22
urinary tract	0/29
uterus	0/5

Expression Distribution

B cell proliferation involved in immune response
B cell homeostasis
immunoglobulin production involved in immunoglobulin mediated immune response
B cell proliferation
B cell activation involved in immune response
lymphocyte homeostasis
leukocyte homeostasis
lymphocyte proliferation
mononuclear cell proliferation
leukocyte proliferation
lymphocyte activation involved in immune response
B cell activation
immunoglobulin production
production of molecular mediator of immune response
homeostasis of number of cells
immunoglobulin mediated immune response
B cell mediated immunity
lymphocyte mediated immunity
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
lymphocyte activation
cell population proliferation
adaptive immune response
leukocyte activation involved in immune response
cell activation involved in immune response
leukocyte mediated immunity
leukocyte activation
cell activation
immune effector process
homeostatic process
immune response