GAS2

Entrez Summary: N/A
UniProt Summary: May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

initiation of primordial ovarian follicle growth
antral ovarian follicle growth
ovulation
basement membrane organization
ovulation cycle process
ovarian follicle development
ovulation cycle
actin filament
female gonad development
development of primary female sexual characteristics
regulation of Notch signaling pathway
female sex differentiation
female gamete generation
cell cycle arrest
regulation of cell shape
gonad development
development of primary sexual characteristics
microtubule binding
sex differentiation
rhythmic process
extracellular matrix organization
extracellular structure organization
developmental growth
growth
reproductive structure development
reproductive system development
regulation of cell morphogenesis
negative regulation of cell cycle
developmental process involved in reproduction
gamete generation
multicellular organismal reproductive process
sexual reproduction
multicellular organism reproduction
apoptotic process
multi-organism reproductive process
cell cycle process
programmed cell death
regulation of anatomical structure morphogenesis
cell death
regulation of cell cycle