GAS2L1 [The Human Chemical-Genetic Interaction Map Project]

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======= GAS2L1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GAS2L1
  * **<color #00a2e8>Official Name</color>**: growth arrest specific 2 like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10634|10634]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99501|Q99501]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GAS2L1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GAS2L1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602128|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Jul 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Seems to be involved in the cross-linking of microtubules and microfilaments. {ECO:0000269|PubMed:12584248}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GAS2|
|CH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cytoskeletal adaptor activity|
|cellular response to thyroid hormone stimulus|
|response to thyroid hormone|
|thyroid hormone receptor binding|
|cell cycle arrest|
|cellular response to starvation|
|response to starvation|
|cellular response to nutrient levels|
|microtubule binding|
|cellular response to extracellular stimulus|
|cellular response to external stimulus|
|cytoskeleton|
|response to nutrient levels|
|response to extracellular stimulus|
|negative regulation of cell cycle|
|cellular response to hormone stimulus|
|response to hormone|
|cell cycle process|
|regulation of cell cycle|
|cellular response to endogenous stimulus|
|cell cycle|
|response to endogenous stimulus|
|cellular response to stress|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.93|
|[[:results:exp380|NMS-873 0.07μM R07 exp380]]|1.76|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|1.79|
|[[:results:exp390|Pifithrin-alpha 20μM R07 exp390]]|1.79|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4316
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GAS2L1 Expression in NALM6 Cells: 1.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>