GAS2L1

Entrez Summary: This gene encodes a member of the growth arrest-specific 2 protein family. This protein binds components of the cytoskeleton and may be involved in mediating interactions between microtubules and microfilaments. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 9. [provided by RefSeq, Jul 2013].
UniProt Summary: Seems to be involved in the cross-linking of microtubules and microfilaments. {ECO:0000269|PubMed:12584248}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GAS2
CH

cytoskeletal adaptor activity
cellular response to thyroid hormone stimulus
response to thyroid hormone
thyroid hormone receptor binding
cell cycle arrest
cellular response to starvation
response to starvation
cellular response to nutrient levels
microtubule binding
cellular response to extracellular stimulus
cellular response to external stimulus
cytoskeleton
response to nutrient levels
response to extracellular stimulus
negative regulation of cell cycle
cellular response to hormone stimulus
response to hormone
cell cycle process
regulation of cell cycle
cellular response to endogenous stimulus
cell cycle
response to endogenous stimulus
cellular response to stress