GATA6

Gene Information

Official Symbol: GATA6
Official Name: GATA binding protein 6
Aliases and Previous Symbols: N/A
Entrez ID: 2627
UniProt: Q92908
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects. [provided by RefSeq, Mar 2012].
UniProt Summary: Transcriptional activator (PubMed:19666519, PubMed:27756709, PubMed:22750565, PubMed:22824924). Regulates SEMA3C and PLXNA2 (PubMed:19666519). Involved in gene regulation specifically in the gastric epithelium (PubMed:9315713). May regulate genes that protect epithelial cells from bacterial infection (PubMed:16968778). Involved in bone morphogenetic protein (BMP)-mediated cardiac-specific gene expression (By similarity). Binds to BMP response element (BMPRE) DNA sequences within cardiac activating regions (By similarity). {ECO:0000250|UniProtKB:Q61169, ECO:0000269|PubMed:16968778, ECO:0000269|PubMed:19666519, ECO:0000269|PubMed:22750565, ECO:0000269|PubMed:22824924, ECO:0000269|PubMed:27756709, ECO:0000269|PubMed:9315713}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 9207
Expression level (log2 read counts): -5.28

Expression Distribution

GATA
GATA-N

negative regulation of transforming growth factor beta2 production
endodermal cell fate determination
positive regulation of cardiac muscle myoblast proliferation
regulation of cardiac muscle myoblast proliferation
Clara cell differentiation
type II pneumocyte differentiation
negative regulation of transforming growth factor beta1 production
cardiac vascular smooth muscle cell differentiation
positive regulation of cardioblast differentiation
pancreatic A cell differentiation
regulation of cardioblast differentiation
lung saccule development
regulation of transforming growth factor beta2 production
positive regulation of myoblast proliferation
lung secretory cell differentiation
negative regulation of transforming growth factor beta production
regulation of transforming growth factor beta1 production
regulation of myoblast proliferation
endodermal cell fate commitment
cardiac muscle hypertrophy in response to stress
cardiac muscle adaptation
vascular smooth muscle cell differentiation
muscle hypertrophy in response to stress
cellular response to gonadotropin stimulus
type B pancreatic cell differentiation
intestinal epithelial cell differentiation
enteroendocrine cell differentiation
lung epithelial cell differentiation
positive regulation of stem cell differentiation
lung cell differentiation
positive regulation of cardiac muscle cell proliferation
striated muscle adaptation
cell fate commitment involved in formation of primary germ layer
outflow tract septum morphogenesis
response to gonadotropin
positive regulation of cardiocyte differentiation
cardiac muscle hypertrophy
lung epithelium development
striated muscle hypertrophy
muscle adaptation