GCG

Gene Information

Official Symbol: GCG
Official Name: glucagon
Aliases and Previous Symbols: N/A
Entrez ID: 2641
UniProt: P01275
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability. Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15442
Expression level (log2 read counts): -7.68

Expression Distribution

glucagon receptor binding
positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter
regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
regulation of carbohydrate metabolic process by regulation of transcription from RNA polymerase II promoter
protein kinase A signaling
positive regulation of gluconeogenesis
positive regulation of histone H3-K4 methylation
positive regulation of calcium ion import
negative regulation of execution phase of apoptosis
cellular response to glucagon stimulus
regulation of histone H3-K4 methylation
positive regulation of peptidyl-threonine phosphorylation
positive regulation of insulin secretion involved in cellular response to glucose stimulus
response to glucagon
positive regulation of glucose metabolic process
positive regulation of histone methylation
regulation of calcium ion import
regulation of execution phase of apoptosis
regulation of peptidyl-threonine phosphorylation
regulation of gluconeogenesis
regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of cellular carbohydrate metabolic process
regulation of histone methylation
positive regulation of insulin secretion
positive regulation of carbohydrate metabolic process
feeding behavior
positive regulation of histone modification
positive regulation of protein binding
regulation of carbohydrate biosynthetic process
positive regulation of peptide hormone secretion
hormone activity
positive regulation of chromatin organization
positive regulation of peptidyl-serine phosphorylation
regulation of glucose metabolic process
secretory granule lumen
positive regulation of calcium ion transport
positive regulation of hormone secretion
adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of peptidyl-serine phosphorylation
positive regulation of small molecule metabolic process