GCHFR [The Human Chemical-Genetic Interaction Map Project]

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======= GCHFR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GCHFR
  * **<color #00a2e8>Official Name</color>**: GTP cyclohydrolase I feedback regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2644|2644]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P30047|P30047]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GCHFR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GCHFR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602437|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. {ECO:0000269|PubMed:16778797}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GFRP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GTP cyclohydrolase binding|
|negative regulation of GTP cyclohydrolase I activity|
|regulation of GTP cyclohydrolase I activity|
|nitric oxide biosynthetic process|
|nitric oxide metabolic process|
|amino acid binding|
|reactive nitrogen species metabolic process|
|GTP-dependent protein binding|
|reactive oxygen species biosynthetic process|
|enzyme inhibitor activity|
|neurotransmitter biosynthetic process|
|neurotransmitter metabolic process|
|melanosome|
|protein heterooligomerization|
|reactive oxygen species metabolic process|
|nuclear membrane|
|regulation of neurotransmitter levels|
|dendrite|
|cofactor metabolic process|
|negative regulation of hydrolase activity|
|drug metabolic process|
|protein complex oligomerization|
|protein-containing complex|
|negative regulation of catalytic activity|
|negative regulation of molecular function|
|regulation of hydrolase activity|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|cellular nitrogen compound biosynthetic process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4799
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -0.97 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GCHFR Expression in NALM6 Cells: -0.97'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>