GCHFR

Entrez Summary: N/A
UniProt Summary: Mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase 1. This inhibition is reversed by L-phenylalanine. {ECO:0000269|PubMed:16778797}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

GTP cyclohydrolase binding
negative regulation of GTP cyclohydrolase I activity
regulation of GTP cyclohydrolase I activity
nitric oxide biosynthetic process
nitric oxide metabolic process
amino acid binding
reactive nitrogen species metabolic process
GTP-dependent protein binding
reactive oxygen species biosynthetic process
enzyme inhibitor activity
neurotransmitter biosynthetic process
neurotransmitter metabolic process
melanosome
protein heterooligomerization
reactive oxygen species metabolic process
nuclear membrane
regulation of neurotransmitter levels
dendrite
cofactor metabolic process
negative regulation of hydrolase activity
drug metabolic process
protein complex oligomerization
protein-containing complex
negative regulation of catalytic activity
negative regulation of molecular function
regulation of hydrolase activity
negative regulation of biosynthetic process
protein-containing complex assembly
cellular nitrogen compound biosynthetic process
protein-containing complex subunit organization