GCNT1

Entrez Summary: N/A
UniProt Summary: Glycosyltransferase that catalyzes the transfer of an N- acetylglucosamine moiety onto mucin-type core 1 O-glycan to form the branched mucin-type core 2 O-glycan. Mucin-type core 2 O- glycans play an important role in leukocyte extravasation as they serve as scaffolds for the display of the selectin ligand sialyl Lewis X by leukocytes. {ECO:0000269|PubMed:23027862}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cell adhesion molecule production
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
Golgi cisterna
leukocyte tethering or rolling
leukocyte adhesion to vascular endothelial cell
cellular extravasation
leukocyte cell-cell adhesion
O-glycan processing
kidney morphogenesis
protein O-linked glycosylation
trans-Golgi network
response to insulin
macromolecule glycosylation
protein glycosylation
glycosylation
kidney development
renal system development
urogenital system development
glycoprotein biosynthetic process
leukocyte migration
glycoprotein metabolic process
response to peptide hormone
response to peptide
cell-cell adhesion
tissue morphogenesis
carbohydrate derivative biosynthetic process
Golgi membrane
response to hormone
cell adhesion
biological adhesion
animal organ morphogenesis
cell migration
response to organonitrogen compound
carbohydrate derivative metabolic process
cell motility
localization of cell
response to nitrogen compound
locomotion
organonitrogen compound biosynthetic process
response to endogenous stimulus