GCNT2 [The Human Chemical-Genetic Interaction Map Project]

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======= GCNT2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GCNT2
  * **<color #00a2e8>Official Name</color>**: glucosaminyl (N-acetyl) transferase 2 (I blood group)
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=2651|2651]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N0V5|Q8N0V5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GCNT2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GCNT2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600429|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. {ECO:0000269|PubMed:7579796, ECO:0000269|PubMed:8449405}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Branch|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity|
|maintenance of lens transparency|
|positive regulation of heterotypic cell-cell adhesion|
|regulation of heterotypic cell-cell adhesion|
|positive regulation of epithelial to mesenchymal transition|
|negative regulation of cell-substrate adhesion|
|regulation of epithelial to mesenchymal transition|
|transforming growth factor beta receptor signaling pathway|
|glycosaminoglycan biosynthetic process|
|aminoglycan biosynthetic process|
|cellular response to transforming growth factor beta stimulus|
|glycosaminoglycan metabolic process|
|response to transforming growth factor beta|
|positive regulation of protein kinase B signaling|
|aminoglycan metabolic process|
|tissue homeostasis|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|positive regulation of ERK1 and ERK2 cascade|
|regulation of cell-substrate adhesion|
|regulation of protein kinase B signaling|
|positive regulation of cell-cell adhesion|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|negative regulation of cell adhesion|
|regulation of ERK1 and ERK2 cascade|
|glycoprotein biosynthetic process|
|multicellular organismal homeostasis|
|anatomical structure homeostasis|
|glycoprotein metabolic process|
|regulation of cell-cell adhesion|
|positive regulation of cell adhesion|
|positive regulation of cell migration|
|cellular response to growth factor stimulus|
|positive regulation of cell motility|
|posttranscriptional regulation of gene expression|
|response to growth factor|
|positive regulation of cellular component movement|
|positive regulation of MAPK cascade|
|positive regulation of locomotion|
|Golgi membrane|
|carbohydrate derivative biosynthetic process|
|regulation of cell adhesion|
|enzyme linked receptor protein signaling pathway|
|regulation of MAPK cascade|
|regulation of cell migration|
|regulation of cell motility|
|positive regulation of cell population proliferation|
|positive regulation of cell differentiation|
|regulation of locomotion|
|Golgi apparatus|
|regulation of cellular component movement|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|carbohydrate derivative metabolic process|
|positive regulation of phosphorylation|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|positive regulation of developmental process|
|organonitrogen compound biosynthetic process|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|regulation of cell population proliferation|
|homeostatic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|positive regulation of multicellular organismal process|
|macromolecule biosynthetic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp475|CyclicAMP 200μM R08 exp475]]|-1.91|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.71|
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|1.8|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.99|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|2.02|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13847
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GCNT2 Expression in NALM6 Cells: 2.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>