GCNT2

Gene Information

Official Symbol: GCNT2
Official Name: glucosaminyl (N-acetyl) transferase 2 (I blood group)
Aliases and Previous Symbols: N/A
Entrez ID: 2651
UniProt: Q8N0V5
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].
UniProt Summary: Branching enzyme that converts linear into branched poly-N-acetyllactosaminoglycans. Introduces the blood group I antigen during embryonic development. It is closely associated with the development and maturation of erythroid cells. {ECO:0000269|PubMed:7579796, ECO:0000269|PubMed:8449405}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
CyclicAMP 200μM R08 exp475	-1.91
Thioridazine 5μM R08 exp530	1.71
Mubritinib 0.2μM R01 exp48	1.8
Ethanol 0.01 R05 exp234	1.99
Cisplatin 0.35μM R06 exp273	2.02

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13847
Expression level (log2 read counts): 2.28

Expression Distribution

N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
maintenance of lens transparency
positive regulation of heterotypic cell-cell adhesion
regulation of heterotypic cell-cell adhesion
positive regulation of epithelial to mesenchymal transition
negative regulation of cell-substrate adhesion
regulation of epithelial to mesenchymal transition
transforming growth factor beta receptor signaling pathway
glycosaminoglycan biosynthetic process
aminoglycan biosynthetic process
cellular response to transforming growth factor beta stimulus
glycosaminoglycan metabolic process
response to transforming growth factor beta
positive regulation of protein kinase B signaling
aminoglycan metabolic process
tissue homeostasis
transmembrane receptor protein serine/threonine kinase signaling pathway
positive regulation of ERK1 and ERK2 cascade
regulation of cell-substrate adhesion
regulation of protein kinase B signaling
positive regulation of cell-cell adhesion
protein glycosylation
macromolecule glycosylation
glycosylation
negative regulation of cell adhesion
regulation of ERK1 and ERK2 cascade
glycoprotein biosynthetic process
multicellular organismal homeostasis
anatomical structure homeostasis
glycoprotein metabolic process
regulation of cell-cell adhesion
positive regulation of cell adhesion
positive regulation of cell migration
cellular response to growth factor stimulus
positive regulation of cell motility
posttranscriptional regulation of gene expression
response to growth factor
positive regulation of cellular component movement
positive regulation of MAPK cascade
positive regulation of locomotion