GCNT3

Entrez Summary: N/A
UniProt Summary: Glycosyltransferase that can synthesize all known mucin beta 6 N-acetylglucosaminides. Mediates core 2 and core 4 O-glycan branching, 2 important steps in mucin-type biosynthesis. Has also I-branching enzyme activity by converting linear into branched poly-N-acetyllactosaminoglycans, leading to introduce the blood group I antigen during embryonic development. {ECO:0000269|PubMed:9915862}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

immunoglobulin production in mucosal tissue
acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity
beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
immunoglobulin production involved in immunoglobulin mediated immune response
mucosal immune response
organ or tissue specific immune response
intestinal absorption
O-glycan processing
digestive system process
kidney morphogenesis
protein O-linked glycosylation
digestion
immunoglobulin production
production of molecular mediator of immune response
immunoglobulin mediated immune response
B cell mediated immunity
protein glycosylation
macromolecule glycosylation
lymphocyte mediated immunity
glycosylation
kidney development
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
renal system development
urogenital system development
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate metabolic process
tissue morphogenesis
adaptive immune response
carbohydrate derivative biosynthetic process
Golgi membrane
leukocyte mediated immunity
animal organ morphogenesis
carbohydrate derivative metabolic process
immune effector process
organonitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
tissue development
macromolecule biosynthetic process