GDF11

Entrez Summary: N/A
UniProt Summary: Secreted signal that acts globally to specify positional identity along the anterior/posterior axis during development. May play critical roles in patterning both mesodermal and neural tissues and in establishing the skeletal pattern (By similarity). Signals through activin receptors type-2, ACVR2A and ACVR2B, and activin receptors type-1, ACVR1B, ACVR1C and TGFBR1 leading to the phosphorylation of SMAD2 and SMAD3 (PubMed:28257634). {ECO:0000250|UniProtKB:Q9Z1W4, ECO:0000269|PubMed:28257634}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

TGFb propeptide
TGF beta

spinal cord anterior/posterior patterning
spinal cord patterning
transforming growth factor beta receptor binding
positive regulation of pathway-restricted SMAD protein phosphorylation
SMAD protein signal transduction
regulation of pathway-restricted SMAD protein phosphorylation
pancreas development
metanephros development
ureteric bud development
mesonephric tubule development
mesonephric epithelium development
roof of mouth development
mesonephros development
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
spinal cord development
camera-type eye morphogenesis
mesoderm development
kidney epithelium development
eye morphogenesis
cell maturation
growth factor activity
cytokine activity
transmembrane receptor protein serine/threonine kinase signaling pathway
anterior/posterior pattern specification
negative regulation of neuron differentiation
regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
developmental maturation
sensory organ morphogenesis
kidney development
renal system development
negative regulation of neurogenesis
negative regulation of nervous system development
camera-type eye development
urogenital system development
regionalization
negative regulation of cell development
eye development
visual system development
sensory system development
pattern specification process