GDF7 [The Human Chemical-Genetic Interaction Map Project]

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======= GDF7 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GDF7
  * **<color #00a2e8>Official Name</color>**: growth differentiation factor 7
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=151449|151449]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q7Z4P5|Q7Z4P5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GDF7&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GDF7|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604651|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play an active role in the motor area of the primate neocortex. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TGF beta|
|TGFb propeptide|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of tendon cell differentiation|
|regulation of tendon cell differentiation|
|roof plate formation|
|forebrain morphogenesis|
|pathway-restricted SMAD protein phosphorylation|
|spinal cord association neuron differentiation|
|morphogenesis of an epithelial fold|
|dorsal spinal cord development|
|activin receptor signaling pathway|
|brain morphogenesis|
|transforming growth factor beta receptor binding|
|positive regulation of pathway-restricted SMAD protein phosphorylation|
|cell differentiation in spinal cord|
|SMAD protein signal transduction|
|regulation of pathway-restricted SMAD protein phosphorylation|
|midbrain development|
|BMP signaling pathway|
|gland morphogenesis|
|positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|neural tube formation|
|spinal cord development|
|embryonic epithelial tube formation|
|branching morphogenesis of an epithelial tube|
|epithelial tube formation|
|morphogenesis of embryonic epithelium|
|tube formation|
|morphogenesis of a branching epithelium|
|neural tube development|
|growth factor activity|
|morphogenesis of a branching structure|
|cytokine activity|
|central nervous system neuron differentiation|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|cell fate commitment|
|axon guidance|
|neuron projection guidance|
|epithelial tube morphogenesis|
|positive regulation of neuron differentiation|
|axonogenesis|
|forebrain development|
|axon development|
|gland development|
|reproductive structure development|
|reproductive system development|
|cell morphogenesis involved in neuron differentiation|
|morphogenesis of an epithelium|
|positive regulation of neurogenesis|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cellular response to growth factor stimulus|
|cell part morphogenesis|
|response to growth factor|
|positive regulation of nervous system development|
|positive regulation of cell development|
|chemotaxis|
|taxis|
|cell morphogenesis involved in differentiation|
|tissue morphogenesis|
|embryonic morphogenesis|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|regulation of neuron differentiation|
|neuron projection development|
|developmental process involved in reproduction|
|epithelial cell differentiation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|brain development|
|regulation of MAPK cascade|
|head development|
|neuron development|
|regulation of neurogenesis|
|cellular component morphogenesis|
|tube development|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|regulation of nervous system development|
|regulation of cell development|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|protein phosphorylation|
|embryo development|
|central nervous system development|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of phosphorylation|
|regulation of anatomical structure morphogenesis|
|epithelium development|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|cell projection organization|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|phosphorylation|
|locomotion|
|positive regulation of developmental process|
|reproductive process|
|reproduction|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|generation of neurons|
|regulation of apoptotic process|
|positive regulation of transcription, DNA-templated|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|tissue development|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15197
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GDF7 Expression in NALM6 Cells: 0.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>