GDF7
Gene Information
- Official Symbol: GDF7
- Official Name: growth differentiation factor 7
- Aliases and Previous Symbols: N/A
- Entrez ID: 151449
- UniProt: Q7Z4P5
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play an active role in the motor area of the primate neocortex. {ECO:0000250}.
Pfam Domains GO Terms
Pfam Domains
| TGF beta |
| TGFb propeptide |
GO Terms
| positive regulation of tendon cell differentiation |
| regulation of tendon cell differentiation |
| roof plate formation |
| forebrain morphogenesis |
| pathway-restricted SMAD protein phosphorylation |
| spinal cord association neuron differentiation |
| morphogenesis of an epithelial fold |
| dorsal spinal cord development |
| activin receptor signaling pathway |
| brain morphogenesis |
| transforming growth factor beta receptor binding |
| positive regulation of pathway-restricted SMAD protein phosphorylation |
| cell differentiation in spinal cord |
| SMAD protein signal transduction |
| regulation of pathway-restricted SMAD protein phosphorylation |
| midbrain development |
| BMP signaling pathway |
| gland morphogenesis |
| positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| cellular response to BMP stimulus |
| response to BMP |
| neural tube formation |
| spinal cord development |
| embryonic epithelial tube formation |
| branching morphogenesis of an epithelial tube |
| epithelial tube formation |
| morphogenesis of embryonic epithelium |
| tube formation |
| morphogenesis of a branching epithelium |
| neural tube development |
| growth factor activity |
| morphogenesis of a branching structure |
| cytokine activity |
| central nervous system neuron differentiation |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| cell fate commitment |
| axon guidance |
| neuron projection guidance |
| epithelial tube morphogenesis |
| positive regulation of neuron differentiation |
| axonogenesis |
| forebrain development |
| axon development |
| gland development |
| reproductive structure development |
| reproductive system development |
| cell morphogenesis involved in neuron differentiation |
| morphogenesis of an epithelium |
| positive regulation of neurogenesis |
| neuron projection morphogenesis |
| plasma membrane bounded cell projection morphogenesis |
| cell projection morphogenesis |
| cellular response to growth factor stimulus |
| cell part morphogenesis |
| response to growth factor |
| positive regulation of nervous system development |
| positive regulation of cell development |
| chemotaxis |
| taxis |
| cell morphogenesis involved in differentiation |
| tissue morphogenesis |
| embryonic morphogenesis |
| chordate embryonic development |
| embryo development ending in birth or egg hatching |
| tube morphogenesis |
| regulation of neuron differentiation |
| neuron projection development |
| developmental process involved in reproduction |
| epithelial cell differentiation |
| enzyme linked receptor protein signaling pathway |
| cell morphogenesis |
| brain development |
| regulation of MAPK cascade |
| head development |
| neuron development |
| regulation of neurogenesis |
| cellular component morphogenesis |
| tube development |
| protein homodimerization activity |
| anatomical structure formation involved in morphogenesis |
| regulation of nervous system development |
| regulation of cell development |
| animal organ morphogenesis |
| positive regulation of cell differentiation |
| protein phosphorylation |
| embryo development |
| central nervous system development |
| neuron differentiation |
| positive regulation of protein phosphorylation |
| positive regulation of phosphorylation |
| regulation of anatomical structure morphogenesis |
| epithelium development |
| plasma membrane bounded cell projection organization |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| cell projection organization |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| phosphorylation |
| locomotion |
| positive regulation of developmental process |
| reproductive process |
| reproduction |
| regulation of protein phosphorylation |
| response to endogenous stimulus |
| generation of neurons |
| regulation of apoptotic process |
| positive regulation of transcription, DNA-templated |
| movement of cell or subcellular component |
| regulation of programmed cell death |
| regulation of phosphorylation |
| extracellular space |
| positive regulation of cellular protein metabolic process |
| neurogenesis |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| cell development |
| positive regulation of signal transduction |
| regulation of cell death |
| positive regulation of protein metabolic process |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15197
- Expression level (log2 read counts): 0.65
Expression Distribution
GDF7 Expression in NALM6 Cells: 0.65
