GDPD5 [The Human Chemical-Genetic Interaction Map Project]

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======= GDPD5 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: GDPD5
  * **<color #00a2e8>Official Name</color>**: glycerophosphodiester phosphodiesterase domain containing 5
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=81544|81544]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8WTR4|Q8WTR4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=GDPD5&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20GDPD5|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609632|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GDPD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|glycerophosphocholine phosphodiesterase activity|
|regulation of timing of cell differentiation|
|regulation of development, heterochronic|
|perinuclear endoplasmic reticulum|
|cerebral cortex neuron differentiation|
|phosphatidylinositol phospholipase C activity|
|spinal cord motor neuron differentiation|
|negative regulation of Notch signaling pathway|
|ventral spinal cord development|
|cell differentiation in spinal cord|
|regulation of Notch signaling pathway|
|spinal cord development|
|growth cone|
|central nervous system neuron differentiation|
|positive regulation of neuron differentiation|
|neuronal cell body|
|positive regulation of cell cycle|
|forebrain development|
|positive regulation of neurogenesis|
|positive regulation of nervous system development|
|positive regulation of cell development|
|regulation of neuron differentiation|
|neuron projection development|
|brain development|
|head development|
|neuron development|
|regulation of neurogenesis|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|central nervous system development|
|neuron differentiation|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|regulation of cell cycle|
|lipid metabolic process|
|negative regulation of signal transduction|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of developmental process|
|generation of neurons|
|negative regulation of response to stimulus|
|neurogenesis|
|cell development|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 4566
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.65 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='GDPD5 Expression in NALM6 Cells: 3.65'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>