GDPD5

Entrez Summary: N/A
UniProt Summary: Promotes neurite formation. Cooperates with PRDX1 to drive postmitotic motor neuron differentiation. The glycerophosphodiester phosphodiesterase activity may be required for its role in neuronal differentiation. May contribute to the osmotic regulation of cellular glycerophosphocholine.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

glycerophosphocholine phosphodiesterase activity
regulation of timing of cell differentiation
regulation of development, heterochronic
perinuclear endoplasmic reticulum
cerebral cortex neuron differentiation
phosphatidylinositol phospholipase C activity
spinal cord motor neuron differentiation
negative regulation of Notch signaling pathway
ventral spinal cord development
cell differentiation in spinal cord
regulation of Notch signaling pathway
spinal cord development
growth cone
central nervous system neuron differentiation
positive regulation of neuron differentiation
neuronal cell body
positive regulation of cell cycle
forebrain development
positive regulation of neurogenesis
positive regulation of nervous system development
positive regulation of cell development
regulation of neuron differentiation
neuron projection development
brain development
head development
neuron development
regulation of neurogenesis
regulation of nervous system development
regulation of cell development
positive regulation of cell differentiation
central nervous system development
neuron differentiation
plasma membrane bounded cell projection organization
cell projection organization
regulation of cell cycle
lipid metabolic process
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
positive regulation of developmental process