GEM

Gene Information

Official Symbol: GEM
Official Name: GTP binding protein overexpressed in skeletal muscle
Aliases and Previous Symbols: N/A
Entrez ID: 2669
UniProt: P55040
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Could be a regulatory protein, possibly participating in receptor-mediated signal transduction at the plasma membrane. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 15829
Expression level (log2 read counts): -5.6

Expression Distribution

Ras
Miro
FeoB N

negative regulation of high voltage-gated calcium channel activity
negative regulation of voltage-gated calcium channel activity
regulation of high voltage-gated calcium channel activity
spindle midzone
negative regulation of calcium ion transmembrane transporter activity
regulation of voltage-gated calcium channel activity
calcium channel regulator activity
negative regulation of calcium ion transmembrane transport
negative regulation of cation channel activity
cytoplasmic side of plasma membrane
metaphase plate congression
negative regulation of calcium ion transport
negative regulation of ion transmembrane transporter activity
establishment of chromosome localization
chromosome localization
GDP binding
mitotic spindle
negative regulation of transporter activity
negative regulation of cation transmembrane transport
regulation of calcium ion transmembrane transporter activity
negative regulation of ion transmembrane transport
negative regulation of transmembrane transport
negative regulation of ion transport
regulation of calcium ion transmembrane transport
midbody
regulation of cation channel activity
calmodulin binding
magnesium ion binding
nuclear chromosome segregation
regulation of calcium ion transport
regulation of ion transmembrane transporter activity
regulation of transmembrane transporter activity
chromosome segregation
regulation of transporter activity
GTPase activity
regulation of cation transmembrane transport
establishment of organelle localization
regulation of metal ion transport
GTP binding
regulation of ion transmembrane transport