GGA2

Official Symbol: GGA2
Official Name: golgi associated, gamma adaptin ear containing, ARF binding protein 2
Aliases and Previous Symbols: N/A
Entrez ID: 23062
UniProt: Q9UJY4
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Plays a role in protein sorting and trafficking between the trans-Golgi network (TGN) and endosomes. Mediates the ARF- dependent recruitment of clathrin to the TGN and binds ubiquitinated proteins and membrane cargo molecules with a cytosolic acidic cluster-dileucine (AC-LL) motif.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

ADP-ribosylation factor binding
protein localization to cell surface
Golgi to plasma membrane protein transport
establishment of protein localization to plasma membrane
clathrin-coated vesicle
Golgi to plasma membrane transport
vesicle-mediated transport to the plasma membrane
post-Golgi vesicle-mediated transport
early endosome membrane
trans-Golgi network
protein localization to plasma membrane
endosome membrane
protein localization to cell periphery
establishment of protein localization to membrane
Golgi vesicle transport
protein localization to membrane
Golgi apparatus
intracellular protein transport
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization
establishment of localization in cell
nitrogen compound transport
vesicle-mediated transport