GHRH
Gene Information
- Official Symbol: GHRH
- Official Name: growth hormone releasing hormone
- Aliases and Previous Symbols: N/A
- Entrez ID: 2691
- UniProt: P01286
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone.
Pfam Domains GO Terms
Pfam Domains
| Hormone 2 |
GO Terms
| positive regulation of circadian sleep/wake cycle, REM sleep |
| growth hormone-releasing hormone receptor binding |
| growth hormone-releasing hormone activity |
| regulation of circadian sleep/wake cycle, REM sleep |
| positive regulation of circadian sleep/wake cycle, sleep |
| growth hormone secretion |
| positive regulation of growth hormone secretion |
| peptide hormone receptor binding |
| regulation of growth hormone secretion |
| positive regulation of insulin-like growth factor receptor signaling pathway |
| adenohypophysis development |
| positive regulation of circadian rhythm |
| regulation of circadian sleep/wake cycle, sleep |
| regulation of circadian sleep/wake cycle |
| response to food |
| regulation of insulin-like growth factor receptor signaling pathway |
| neuropeptide hormone activity |
| positive regulation of behavior |
| positive regulation of multicellular organism growth |
| pituitary gland development |
| terminal bouton |
| peptide hormone secretion |
| regulation of multicellular organism growth |
| regulation of behavior |
| hormone secretion |
| diencephalon development |
| hormone transport |
| positive regulation of peptide hormone secretion |
| regulation of circadian rhythm |
| endocrine system development |
| positive regulation of hormone secretion |
| adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| perikaryon |
| cAMP-mediated signaling |
| signal release |
| positive regulation of developmental growth |
| cyclic-nucleotide-mediated signaling |
| peptide secretion |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| regulation of peptide hormone secretion |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger |
| positive regulation of growth |
| regulation of hormone secretion |
| positive regulation of peptide secretion |
| neuron projection |
| regulation of developmental growth |
| second-messenger-mediated signaling |
| forebrain development |
| positive regulation of secretion by cell |
| gland development |
| positive regulation of secretion |
| regulation of peptide secretion |
| response to nutrient levels |
| response to extracellular stimulus |
| regulation of hormone levels |
| regulation of growth |
| regulation of peptide transport |
| brain development |
| regulation of secretion by cell |
| head development |
| regulation of secretion |
| positive regulation of cell population proliferation |
| central nervous system development |
| positive regulation of transport |
| secretion by cell |
| export from cell |
| cell-cell signaling |
| secretion |
| G protein-coupled receptor signaling pathway |
| positive regulation of developmental process |
| peptide transport |
| amide transport |
| extracellular space |
| regulation of cell population proliferation |
| positive regulation of signal transduction |
| intracellular signal transduction |
| positive regulation of multicellular organismal process |
| positive regulation of cell communication |
| positive regulation of signaling |
| nitrogen compound transport |
| regulation of transport |
| extracellular region |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Diepoxybutane 3μM R07 exp354 | 1.72 |
| Adefovir 20μM R07 exp332 | 1.93 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3235
- Expression level (log2 read counts): -6.6
Expression Distribution
GHRH Expression in NALM6 Cells: -6.6
