GIF

Entrez Summary: N/A
UniProt Summary: Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

cobalt ion transport
cobalamin transport
cobalamin binding
cobalamin metabolic process
vitamin transport
cofactor transport
tetrapyrrole metabolic process
microvillus
water-soluble vitamin metabolic process
lysosomal lumen
transition metal ion transport
vitamin metabolic process
drug transport
endosome
divalent inorganic cation transport
apical plasma membrane
cofactor metabolic process
drug metabolic process
metal ion transport
cation transport
response to drug
ion transport
extracellular space
small molecule metabolic process
nitrogen compound transport
extracellular region